Technology Process of (S)-3,4-dibenzoyloxy-1-(tert-butyldimethylsilyloxy)butan-2-one
There total 4 articles about (S)-3,4-dibenzoyloxy-1-(tert-butyldimethylsilyloxy)butan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -60 - 0 ℃;
for 1.25h;
DOI:10.1016/S0040-4020(02)01279-6
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / Et3N; DMAP / CH2Cl2 / 0 - 20 °C
2: 83 percent / trifluoroacetic acid / 0.5 h / 0 °C
3: 91 percent / imidazole / dimethylformamide / 8 h / 0 °C
4: 80 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1.25 h / -60 - 0 °C
With
1H-imidazole; dmap; oxalyl dichloride; dimethyl sulfoxide; triethylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
4: Swern oxidation;
DOI:10.1016/S0040-4020(02)01279-6
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / imidazole / dimethylformamide / 8 h / 0 °C
2: 80 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 1.25 h / -60 - 0 °C
With
1H-imidazole; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
2: Swern oxidation;
DOI:10.1016/S0040-4020(02)01279-6
