6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

Base Information

Chemical Name:6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine
CAS No.:147876-52-6
Molecular Formula:C₂₉H₃₃N₃O₃
Molecular Weight:471.599
Hs Code.:

Synonyms:6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

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Chemical Property of 6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

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Technology Process of 6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

There total 5 articles about 6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 147876-57-1
(6-Butyl-2-oxo-1,2-dihydro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester

: 147876-52-6
6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; for 72h; Heating;
DOI:10.1016/0040-4039(94)02306-V

Reference yield: 34.0%

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 147876-57-1
(6-Butyl-2-oxo-1,2-dihydro-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester

: [6-Butyl-2-(2'-cyano-biphenyl-4-ylmethoxy)-1,2-dihydro-pyridin-3-ylmethyl]-carbamic acid tert-butyl ester

: 147876-52-6
6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

Guidance literature:: In N,N-dimethyl-formamide; Product distribution; regioselectivity of the alkylation in the presence of different bases and solvents;
DOI:10.1016/0040-4039(94)02306-V

Reference yield:

: 591-78-6
n-hexan-2-one

: 147876-52-6
6-butyl-1-(2'-cyanobiphenyl-4-ylmethyl)-1,2-dihydro-2-oxo-3-tert-butoxycarbonylaminomethyl pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 10 percent NH₃

2: 92 percent / n-BuLi / tetrahydrofuran; hexane / 72 h / Heating

With ammonium hydroxide; n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/0040-4039(94)02306-V