6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1335116-45-4
Molecular Formula:C₁₉H₁₃BrF₃NO₃
Molecular Weight:440.216
Hs Code.:

Synonyms:6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Suppliers and Price of 6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 4 articles about 6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 600-18-0
2-Oxobutyric acid

: 454-89-7
3-Trifluoromethylbenzaldehyde

: 19056-40-7
4-bromo-3-methoxyaniline

: 1335116-45-4
6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: 3-Trifluoromethylbenzaldehyde; 4-bromo-3-methoxyaniline; In ethanol; Reflux;

2-Oxobutyric acid; In ethanol; at 20 ℃; Product distribution / selectivity; Reflux;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 130420-85-8
5-bromo-6-methoxy-indoline-2,3-dione

: 1335116-45-4
6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: 3-(trifluoromethyl)propiophenone; 5-bromo-6-methoxy-indoline-2,3-dione; With potassium hydroxide; In ethanol; water; for 16h; Reflux;

With hydrogenchloride; In ethanol; water; pH=3;

Reference yield:

: 19056-40-7
4-bromo-3-methoxyaniline

: 1335116-45-4
6-bromo-3-methyl-7-(methyloxy)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; water / 50 °C

1.2: 1 h / 80 °C

2.1: sulfuric acid / 1 h / 50 - 80 °C

3.1: potassium hydroxide / ethanol; water / 16 h / Reflux

3.2: pH 3

With hydrogenchloride; sulfuric acid; potassium hydroxide; In 1,4-dioxane; ethanol; water;