1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

Base Information

Chemical Name:1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile
CAS No.:797783-26-7
Molecular Formula:C₂₅H₁₉ClN₆O
Molecular Weight:454.918
Hs Code.:

1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3<i>H</i>-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

Synonyms:1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

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Chemical Property of 1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

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Technology Process of 1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

There total 13 articles about 1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-(3-Chloro-phenyl)-6-({[1-[3-(4-cyano-benzyl)-3H-imidazol-4-yl]-meth-(E)-ylidene]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

: 797783-26-7
1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2004.08.012

Reference yield:

: 108-42-9
3-chloro-aniline

: 797783-26-7
1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: 78 percent / t-BuONa / ethanol / 18 h / 90 °C

2.1: CDI / dimethylformamide / 18 h / 110 °C

2.2: 91 percent / NH₃ / dimethylformamide / 18 h / 4 °C

3.1: 38 percent / POCl₃; NMP / 3 h / 20 °C

4.1: 77 percent / SeO₂ / dioxane / Heating

5.1: 69 percent / NaBH(OAc)3 / methanol / 4 h / 20 °C

6.1: 49 percent / PBr₃; LiBr / dimethylformamide / 4 h / 0 °C

7.1: 91 percent / NaN₃ / acetone / 1 h / Heating

8.1: 89 percent / PPh₃; water / tetrahydrofuran / 1 h / Heating

9.1: AcOH / methanol / 1 h / 20 °C

10.1: sodium cyanoborohydride / methanol / 1 h / 20 °C

With 1-methyl-pyrrolidin-2-one; selenium(IV) oxide; sodium azide; water; phosphorus tribromide; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; triphenylphosphine; 1,1'-carbonyldiimidazole; lithium bromide; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.012

Reference yield:

: 181277-21-4
3-(dimethylaminomethine)-4-oxo-6-methyl-2-pyrone

: 797783-26-7
1-(3-chloro-phenyl)-6-({[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-methyl)-4-oxo-1,4-dihydro-pyridine-3-carbonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: 78 percent / t-BuONa / ethanol / 18 h / 90 °C

2.1: CDI / dimethylformamide / 18 h / 110 °C

2.2: 91 percent / NH₃ / dimethylformamide / 18 h / 4 °C

3.1: 38 percent / POCl₃; NMP / 3 h / 20 °C

4.1: 77 percent / SeO₂ / dioxane / Heating

5.1: 69 percent / NaBH(OAc)3 / methanol / 4 h / 20 °C

6.1: 49 percent / PBr₃; LiBr / dimethylformamide / 4 h / 0 °C

7.1: 91 percent / NaN₃ / acetone / 1 h / Heating

8.1: 89 percent / PPh₃; water / tetrahydrofuran / 1 h / Heating

9.1: AcOH / methanol / 1 h / 20 °C

10.1: sodium cyanoborohydride / methanol / 1 h / 20 °C

With 1-methyl-pyrrolidin-2-one; selenium(IV) oxide; sodium azide; water; phosphorus tribromide; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; acetic acid; triphenylphosphine; 1,1'-carbonyldiimidazole; lithium bromide; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmcl.2004.08.012