2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid

Base Information

• Chemical Name: 2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid
• CAS No.: 1246362-38-8
• Molecular Formula: C₂₁H₃₀N₂O₆
• Molecular Weight: 406.479

Synonyms:2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid

Chemical Property of 2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid

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Technology Process of 2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid

There total 1 articles about 2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.3%

C22H32N2O6 (1246362-37-7) → 2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid (1246362-38-8)

Guidance literature:

C₂₂H₃₂N₂O₆; With sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 10h;

With hydrogenchloride; pH=1;

Reference yield: 14.0%

3,3,3-trifluoroprop-1-yne (661-54-1) + 2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid (1246362-38-8) → (R)-benzyl 3-(1-(3-methoxypropyl)-5-methyl-3-(trifluoromethyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate (1246362-42-4) + (R)-benzyl 3-(1-(3-methoxypropyl)-5-methyl-4-(trifluoromethyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate (1246362-41-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In toluene; at -78 - 110 ℃;

Reference yield:

2-((R)-1-(benzyloxycarbonyl)-N-(3-methoxypropyl)piperidine-3-carboxamido)propanoic acid (1246362-38-8) + hexafluoro-2-butyne (692-50-2) → (R)-benzyl 3-(1-(3-methoxypropyl)-5-methyl-3,4-bis(trifluoromethyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate (1246362-39-9)

Guidance literature:

With dicyclohexyl-carbodiimide; at -78 - 110 ℃;

upstream raw materials:

C₂₂H₃₂N₂O₆

Downstream raw materials:

(R)-benzyl 3-(1-(3-methoxypropyl)-5-methyl-3-(trifluoromethyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate

(R)-benzyl 3-(1-(3-methoxypropyl)-5-methyl-4-(trifluoromethyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate

(R)-benzyl 3-(1-(3-methoxypropyl)-5-methyl-3,4-bis(trifluoromethyl)-1H-pyrrol-2-yl)piperidine-1-carboxylate

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