661-54-1

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 1139, 1963 DOI: 10.1021/jo01039a511

InChI:InChI=1/C4H4ClF3/c5-3(6)1-2-4(3,7)8/h1-2H2

Upstream product

• 338-75-0 2,3-dichloro-1,1,1-trifluoropropane 
• 7125-94-2 3,3-dibromo-1,1,1-trifluoro-propane 
• 460-68-4 3-bromo-1,1,1-trifluoro-3-iodo-propane 
• 431-21-0 1,2-Dibromo-3,3,3-trifluoropropane 
• 100312-95-6 C₃⁽³⁾HF₃ 
• 471-25-0 Propiolic acid 
• 7732-18-5 water 
• 29723-42-0 bis(trifluoromethyl-ethynyl)-dimethyl-stannane 
• 102687-65-0 trans-1-chloro-3,3,3-trifluoropropene 
• 51584-24-8 trifluoroallene 
• 99728-16-2 (Z)-1-chloro-3,3,3-trifluoro-1-propene 
• 23153-23-3 1,1,1,3,3-pentachloropropane 
• 754-12-1 2,3,3,3-tetrafluoro-propene 
• 29118-25-0 (Z)-1,3,3,3-tetrafluoropropene 

Downstream Products

• 26885-67-6 E/Z-1-methoxy-3,3,3-trifluoropropene 
• 421-07-8 1,1,1-trifluoropropane 
• 460-40-2 3,3,3-trifluoropropanal 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 71740-87-9 1-Trifluoromethyl-cyclohexa-1,4-diene 
• 56286-84-1 3-trifluoromethyl furan 
• 75-05-8 acetonitrile 
• 94792-93-5 6,6,6-Trifluoro-1-phenyl-4-hexyn-3-ol 
• 113439-92-2 4,4,4-trifluorobut-2-yn-1-ol 
• 74-86-2 acetylene 
• 130654-80-7 1-methoxy-2-(3,3,3-trifluoroprop-1-yn-1-yl)benzene 
• 122961-10-8 1-chloro-3-(3,3,3-trifluoroprop-1-ynyl)benzene 
• 95540-90-2 1-Cyclohexyl-4,4,4-trifluoro-2-butyn-1-ol 
• 95541-03-0 2,4-Dicyclohexyl-5-[2,2,2-trifluoro-eth-(E)-ylidene]-[1,3]dioxolane 

Relevant academic research and scientific papers

Preparation method of E-1, 3, 3, 3-tetrafluoropropene

The invention discloses a preparation method of E-1, 3, 3, 3-tetrafluoropropene, which comprises the following steps: by taking 3, 3, 3-trifluoropropyne or/and an isomer 1, 3, 3-trifluoropropadiene thereof as a raw material, carrying out gas-phase selective fluorination reaction in the presence of a fluorination catalyst to obtain E-1, 3, 3, 3-tetrafluoropropene. The method provided by the invention is mainly used for producing E-1, 3, 3, 3-tetrafluoropropene in a high-efficiency and gas-phase continuous circulation manner.

Preparation method of Z-1-halogen-3, 3, 3-trifluoropropene

The invention discloses a preparation method of Z-1-halogen-3, 3, 3-trifluoropropene. The preparation method comprises the following steps: in the presence of a block catalyst, E-1-halogen-3, 3, 3-trifluoropropene is subjected to a gas phase isomerization reaction in a tubular reactor to obtain Z-1-halogen-3, 3, 3-trifluoropropene, and halogen is fluorine or chlorine. According to the preparation method, 1, 1, 1, 3, 3-pentachloropropane is used as an initial raw material, Z-1-chloro-3, 3, 3-trifluoropropene or Z-1, 3, 3, 3-tetrafluoropropene secondary product is prepared through a gas-phase fluorination reaction and an isomerization reaction, the materials which are not completely reacted are independently circulated through a gas-phase independent circulation process so that the initial raw materials can be almost completely converted into the target product, and finally, the target product is extracted from a process system, and thus liquid waste and waste gas are not generated, and green production is realized.

Method for preparing 3, 3, 3-trifluoropropyne through gas-phase dehydrohalogenation

The invention discloses a method for preparing 3, 3, 3-trifluoropropyne through gas-phase dehydrohalogenation. The method comprises the following steps: taking 1-halogen-3, 3, 3-trifluoropropene or/and 2-halogen-3, 3, 3-trifluoropropene (halogen = F or Cl or Br or I) as a raw material, and carrying out gas-phase dehydrohalogenation reaction in the presence of a catalyst to obtain the 3, 3, 3-trifluoropropyne. The method disclosed by the invention is mainly used for producing the 3, 3, 3-trifluoropropyne in a gas-phase continuous circulation manner at a high conversion rate and high selectivity.

Preparation method of E-1-halogen-3, 3, 3-trifluoropropene

The invention discloses a preparation method of E-1-halogen-3, 3, 3-trifluoropropene. The preparation method comprises the following steps: in the presence of a block catalyst, carrying out gas-phase fluorination reaction on 1, 1, 1, 3, 3-pentachloropropane and hydrogen fluoride in a tubular reactor to obtain a main product E-1-chlorine-3, 3, 3-trifluoropropene and a small amount of product Z-1-chlorine-3, 3, 3-trifluoropropene; furthermore, in the presence of the block catalyst, E-1-chlorine-3, 3, 3-trifluoropropene or/and Z-1-chlorine-3, 3, 3-trifluoropropene and hydrogen fluoride are subjected to a gas-phase fluorination reaction in the tubular reactor, and a main product E-1, 3, 3, 3-tetrafluoropropene is obtained. The one-way yield of the method is high; especially for the second-step process, only HCl in the product flow in the first step needs to be removed, and the remaining substances can be directly used for fluorination reaction after new HF is added. The block catalyst has the characteristics of high activity and long service life.

HFO-1234yf as a CF3-Building Block: Synthesis and Chemistry of CF3-Ynones

Reaction of low cost, readily available 4th generation refrigerant gas 2,3,3,3-tetrafluoropropene (HFO-1234yf) with lithium diisopropylamide (LDA) leads to formation of lithium 3,3,3-trifluoropropynide, addition of which to a range of aldehydes formed CF3-alkynyl alcohol derivatives on multigram scale, which were oxidised using Dess–Martin periodinane (DMP) to give substituted CF3-ynones with minimal purification required. Michael-type additions of alcohol and amine nucleophiles to CF3-ynones are rapid and selective, affording a range of CF3-enone ethers and enaminones in excellent yields with high stereoselectivity for the Z-isomer. By analogous reactions with difunctional nucleophiles, a wide range of CF3-substituted pharmaceutically relevant heterocyclic structures can be accessed, exemplified in the simple synthesis of the anti-arthritis drug celecoxib from HFO-1234yf in just three steps.

METHOD FOR PRODUCING FLUORINE-CONTAINING ALKYNE COMPOUND

PROBLEM TO BE SOLVED: To provide a fluorine-containing alkyne compound in a manner that is convenient and easy to scale up. SOLUTION: The present invention provides a method for producing a fluorine-containing alkyne compound represented by general formula (1): RfC≡CH (1) [where Rf is a fluorine-containing alkyl group], the method including the steps of causing a compound represented by general formula (2): RfCH=CX1 CR2 OH (2) [where Rf is the same as above. X1 is a halogen atom. R's are the same or different to represent a hydrogen atom or an alkyl group] to react with a base at 50°C or more. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

METHOD FOR PRODUCING FLUOROCARBON USING HYDROHALOFLUOROPROPENE

PROBLEM TO BE SOLVED: To provide a method for selectively producing fluorocarbon by efficiently isomerizing a hydrofluoropropene isomer (isomer 1) under the reduction of catalytic performance to produce a corresponding hydrohalofluoropropene isomer (isomer 2) and using the same. SOLUTION: Provided is a method for producing 3,3,3-trifluoropropene by contacting a 1-halogeno-3,3,3-trifluoropropene isomer with a moisture concentration of 100 ppm or lower (isomer 1) in a vapor phase so as to be isomerized to produce a corresponding 1-halogeno-3,3,3-trifluoropropene isomer (isomer 2), and subjecting the 1-halogeno-3,3,3-trifluoropropene isomer (isomer 2) to dehalogenation. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT

PROCESS FOR THE PREPARATION OF TETRAFLUOROPROPENE

A process for producing at least one tetrafluoropropene, the process comprising (i) converting Z-1233zd to TFMA in the presence of at least one base, wherein the process is conducted in the presence of water, and (ii) contacting the TFMA produced in step (i) with hydrogen fluoride (HF) in the presence of a Lewis acid metal halide catalyst to produce reaction product comprising at least one tetrafluoropropene.

One-Step Process for Hexafluoro-2-Butene

Disclosed is a one step process for making of 1,1,1,4,4,4-hexafluoro-2-butene. More specifically, the present invention provides a process for making hexafluoro-2-butene, continuously, from 2-chloro-3,3,3-trifluoropronene using Fe2O3/NiO impregnated carbon catalyst at 600° to 650° C.

Method for producing 3, 3, 3 - [...]

PROBLEM TO BE SOLVED: To provide a method for producing 3,3,3-trifluoropropyne easily executable on an industrial scale and also at a low cost.SOLUTION: (Z)-1-chloro-3,3,3-trifluoropropyne obtained by various production methods is continuously or semicontinuously contacted with the hydroxide of an alkali metal in the presence of water, and the produced 3,3,3-trifluoropropyne is continuously drawn out from the reaction system.