4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester
CAS No.:153790-83-1
Molecular Formula:C₁₈H₂₄Cl₃NO₄
Molecular Weight:424.752
Hs Code.:

Synonyms:4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of 4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

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Technology Process of 4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

There total 3 articles about 4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 110-89-4
piperidine

: 153790-82-0
3-Formyl-4-hydroxy-6-methoxy-2,5-dimethyl-benzoic acid 2,2,2-trichloro-ethyl ester

: 153790-83-1
4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; In acetonitrile; at 25 ℃; for 9h; pH=6;
DOI:10.1021/ja0112341

Reference yield:

: 148238-89-5
ethyl 3-formyl-4,6-dihydroxy-2,5-dimethylbenzoate

: 153790-83-1
4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / H₂SO₄ / 120 h / 25 °C

2: 90 percent / K₂CO₃ / acetone / 3 h / 50 °C

3: 83 percent / sodium cyanoborohydride; acetic acid / acetonitrile / 9 h / 25 °C / pH 6

With sulfuric acid; sodium cyanoborohydride; potassium carbonate; acetic acid; In acetone; acetonitrile;
DOI:10.1021/ja0112341

Reference yield:

: 153790-81-9
3-Formyl-4,6-dihydroxy-2,5-dimethyl-benzoic acid 2,2,2-trichloro-ethyl ester

: 153790-83-1
4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / acetone / 3 h / 50 °C

2: 83 percent / sodium cyanoborohydride; acetic acid / acetonitrile / 9 h / 25 °C / pH 6

With sodium cyanoborohydride; potassium carbonate; acetic acid; In acetone; acetonitrile;
DOI:10.1021/ja0112341