4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester
CAS No.:386746-26-5
Molecular Formula:C₂₄H₃₈Cl₃NO₄Si
Molecular Weight:539.015
Hs Code.:

Synonyms:4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of 4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

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Technology Process of 4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

There total 6 articles about 4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153790-83-1
4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

: 386746-26-5
4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: 4-Hydroxy-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester; With sodium hydride; In tetrahydrofuran; at 25 ℃;

tert-butyldimethylsilyl chloride; With triethylamine; In tetrahydrofuran; at 25 ℃; for 15h; Further stages.;
DOI:10.1021/ja0112341

Reference yield:

: 148238-89-5
ethyl 3-formyl-4,6-dihydroxy-2,5-dimethylbenzoate

: 386746-26-5
4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 61 percent / H₂SO₄ / 120 h / 25 °C

2.1: 90 percent / K₂CO₃ / acetone / 3 h / 50 °C

3.1: 83 percent / sodium cyanoborohydride; acetic acid / acetonitrile / 9 h / 25 °C / pH 6

4.1: NaH / tetrahydrofuran / 25 °C

4.2: 95 percent / triethylamine / tetrahydrofuran / 15 h / 25 °C

With sulfuric acid; sodium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; In tetrahydrofuran; acetone; acetonitrile;
DOI:10.1021/ja0112341

Reference yield:

: 153790-82-0
3-Formyl-4-hydroxy-6-methoxy-2,5-dimethyl-benzoic acid 2,2,2-trichloro-ethyl ester

: 386746-26-5
4-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-3,6-dimethyl-5-piperidin-1-ylmethyl-benzoic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / sodium cyanoborohydride; acetic acid / acetonitrile / 9 h / 25 °C / pH 6

2.1: NaH / tetrahydrofuran / 25 °C

2.2: 95 percent / triethylamine / tetrahydrofuran / 15 h / 25 °C

With sodium hydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ja0112341