1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea

Base Information

• Chemical Name: 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea
• CAS No.: 1350454-78-2
• Molecular Formula: C₂₅H₂₀F₃N₇O₂S
• Molecular Weight: 539.541
• Mol file: 1350454-78-2.mol

Synonyms:1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea

Chemical Property of 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea

There total 6 articles about 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.4%

1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea (1350454-75-9) → 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea (1350454-78-2)

Guidance literature:

1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea; With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

With water; sodium hydrogencarbonate; Saturated solution;

DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

C18H18F3N3O3 → 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea (1350454-78-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

3.1: boron tribromide / dichloromethane / 1.5 h / -78 - 20 °C / Inert atmosphere

3.2: Saturated solution

With palladium 10% on activated carbon; hydrogen; boron tribromide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.08.024

Reference yield:

2-bromo-3'-methoxyacetophenone (5000-65-7) → 1-(2-(4-(6-(3-hydroxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea (1350454-78-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ethanol / 16 h / Reflux

2.1: palladium diacetate; caesium carbonate; triphenylphosphine / N,N-dimethyl-formamide / 12 h / 80 °C

3.1: Oxone / methanol; water / 16 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 8 h / 80 °C

5.1: boron tribromide / dichloromethane / 1.5 h / -78 - 20 °C / Inert atmosphere

5.2: Saturated solution

With Oxone; palladium diacetate; boron tribromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2011.08.024

upstream raw materials:

6-(3-Methoxyphenyl)-5-(2-(methylthio)pyrimidin-4-yl)imidazo[2,1-b]thiazole

1-(2-(4-(6-(3-methoxyphenyl)imidazo[2,1-b]thiazol-5-yl)pyrimidin-2-ylamino)ethyl)-3-(3-(trifluoromethyl)phenyl)urea

2-bromo-3'-methoxyacetophenone

6-(3-methoxyphenyl)imidazo[2,1-b]thiazole