1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Base Information

Chemical Name:1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole
CAS No.:1372540-09-4
Molecular Formula:C₂₁H₂₀Cl₂N₆O
Molecular Weight:443.335
Hs Code.:

Synonyms:1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Suppliers and Price of 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

There total 11 articles about 1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1372540-13-0
1-[(2,3-dichlorophenyl)methyl]-N-[(1E)-(dimethylamino)methylidene]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxamide

: 1372540-09-4
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Guidance literature:: 1-[(2,3-dichlorophenyl)methyl]-N-[(1E)-(dimethylamino)methylidene]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxamide; With hydrazine hydrate; acetic acid; at 130 ℃; for 0.333333h;

With sodium hydrogencarbonate; at 20 ℃;

Reference yield:

: 1372540-10-7
4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine

: 1372540-09-4
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; iron(II) acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 h / 100 °C / Inert atmosphere

2.1: potassium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 2 h / 50 °C

3.1: 2 h / 130 °C

4.1: hydrazine hydrate; acetic acid / 0.33 h / 130 °C

4.2: 20 °C

With water; dihydrogen peroxide; hydrazine hydrate; acetic acid; potassium hydroxide; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; iron(II) acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1372539-83-7
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazol-4-amine

: 1372540-09-4
1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

1.2: 0.5 h / 60 - 80 °C

1.3: 20 °C

2.1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; iron(II) acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 h / 100 °C / Inert atmosphere

3.1: potassium hydroxide; water; dihydrogen peroxide / tetrahydrofuran / 2 h / 50 °C

4.1: 2 h / 130 °C

5.1: hydrazine hydrate; acetic acid / 0.33 h / 130 °C

5.2: 20 °C

With water; hydrogen bromide; dihydrogen peroxide; hydrazine hydrate; acetic acid; potassium hydroxide; zinc; sodium nitrite; 1,1'-bis-(diphenylphosphino)ferrocene; iron(II) acetate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;