4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine

Base Information

• Chemical Name: 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine
• CAS No.: 1372540-10-7
• Molecular Formula: C₁₉H₁₈BrCl₂N₃O
• Molecular Weight: 455.181
• Mol file: 1372540-10-7.mol

Synonyms:4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine

Chemical Property of 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine

There total 12 articles about 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(4-bromo-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine (1372540-59-4) + 1-(bromomethyl)-2,3-dichlorobenzene (57915-78-3) → 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine (1372540-10-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 4h;

Reference yield: 44.0%

1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazol-4-amine (1372539-83-7) → 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine (1372540-10-7)

Guidance literature:

1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazol-4-amine; With hydrogen bromide; sodium nitrite; In water; at 0 - 5 ℃; for 0.25h;

With sodium bromide; In water; at 60 - 80 ℃; for 0.5h;

With sodium carbonate; In water; at 20 ℃;

Reference yield:

6-bromo-1-(2,3-dichlorobenzyl)-2-methyl-4-nitro-1H-benzo[d]imidazole (1372539-84-8) → 4-(4-bromo-1-(2,3-dichlorobenzyl)-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine (1372540-10-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

2.1: water; iron(II) sulfate; iron / ethanol / 3 h / Reflux

3.1: sodium nitrite; hydrogen bromide / water / 0.25 h / 0 - 5 °C

3.2: 0.5 h / 60 - 80 °C

3.3: 20 °C

With water; hydrogen bromide; iron; caesium carbonate; iron(II) sulfate; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; ethanol; water;

upstream raw materials:

1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazol-4-amine

6-bromo-1-(2,3-dichlorobenzyl)-2-methyl-4-nitro-1H-benzo[d]imidazole

4-(3-(2,3-dichlorobenzyl)-2-methyl-7-nitro-3H-benzo[d]imidazol-5-yl)morpholine

2,6-dinitroaniline

Downstream raw materials:

1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxamide

1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-1,2,4-triazol-3-yl)-1H-benzimidazole

1-[(2,3-dichlorophenyl)methyl]-N-[(1E)-(dimethylamino)methylidene]-2-methyl-6-(4-morpholinyl)-1H-benzimidazole-4-carboxamide

1-[(2,3-dichlorophenyl)methyl]-2-methyl-6-(4-morpholinyl)-4-(1H-pyrazol-5-yl)-1H-benzimidazole