Ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate

Base Information

Chemical Name:Ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate
CAS No.:864684-98-0
Molecular Formula:C14H16 N2 O2 S
Molecular Weight:276.35404
Hs Code.:
DSSTox Substance ID:DTXSID30592302
Wikidata:Q82486348
Mol file:864684-98-0.mol

Synonyms:864684-98-0;ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate;2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;DTXSID30592302;2-(2-ethyl-(pyridin-4-yl))-4-methylthiazole-5-carboxylic acid ethyl ester;DB-363940

Suppliers and Price of Ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 498.32

Total 3 raw suppliers

Chemical Property of Ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate

Chemical Property:

Boiling Point:420.0±55.0 °C(Predicted)
PKA:3.05±0.10(Predicted)
PSA：80.32000
Density:1.180±0.06 g/cm3(Predicted)
LogP:3.25260
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:276.09324893
Heavy Atom Count:19
Complexity:314

Purity/Quality:

97% ^*data from raw suppliers

2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=NC=CC(=C1)C2=NC(=C(S2)C(=O)OCC)C

Technology Process of Ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate

There total 2 articles about Ethyl 2-(2-ethylpyridin-4-yl)-4-methyl-1,3-thiazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 536-33-4,5261-38-1
ethionamide

: 609-15-4
ethyl 2-chloro-3-oxo-butyrate

: 864684-98-0
ethyl 2-(2-ethyl-4-pyridyl)-4-methylthiazole-5-carboxylate

Guidance literature:: In ethanol; for 5h; Reflux;
DOI:10.1002/jccs.202000174

Reference yield:

: 536-33-4,5261-38-1
ethionamide

: 84911-18-2,609-13-2
ethyl 2-bromoacetoacetate

: 864684-98-0
ethyl 2-(2-ethyl-4-pyridyl)-4-methylthiazole-5-carboxylate

Guidance literature:: at 70 - 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 864684-98-0
ethyl 2-(2-ethyl-4-pyridyl)-4-methylthiazole-5-carboxylate

: 1384110-97-7
N-(4-bromophenyl)-2-(2-ethylpyridin-4-yl)-4-methylthiazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / methanol; water / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / Inert atmosphere

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;
DOI:10.3987/COM-13-12865