2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

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Chemical Name:2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine
CAS No.:1418296-59-9
Molecular Formula:C₂₁H₂₃ClFN₃Si
Molecular Weight:399.971
Hs Code.:

Synonyms:2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

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Chemical Property of 2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

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Technology Process of 2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

There total 9 articles about 2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 101990-73-2
2-chloro-pyridin-4-ylmethyl chloride

: 1418297-06-9
3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazole

: 1418296-59-9
2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 22h; Reflux;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-59-9
2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran; ethyl acetate / 3 h / 0 - 5 °C / Inert atmosphere

8.1: hydrogenchloride / 1,4-dioxane / 20 °C

9.1: potassium tert-butylate / tetrahydrofuran / 22 h / Reflux

With hydrogenchloride; potassium tert-butylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-59-9
2-chloro-4-[(3-{(Z)-1-fluoro-2-[4-(trimethylsilyl)phenyl]vinyl}-5-methyl-1H-pyrazol-1-yl)-methyl]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran; ethyl acetate / 3 h / 0 - 5 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 22 h / Reflux

With hydrogenchloride; potassium tert-butylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;