N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

Base Information

Chemical Name:N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide
CAS No.:1431470-06-2
Molecular Formula:C₂₄H₃₂N₆O₂S
Molecular Weight:468.623
Hs Code.:

Synonyms:N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

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Chemical Property of N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

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Technology Process of N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

There total 4 articles about N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431469-99-6
2-(2-aminoethylamino)-5-methyl-6-phenyl-3H-thieno[2,3-d]pyrimidin-4-one

: 1197818-53-3
4-(4-methylpiperazin-1-yl)butanoic acid hydrochloride

: 1431470-06-2
N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 4815-38-7
ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate

: 1431470-06-2
N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 18 h / 130 °C / Sealed tube

2: 18 h / 130 °C / Sealed tube

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; N,N-dimethyl-formamide;

Reference yield:

: 176852-92-9
5-methyl-2-methylsulfanyl-6-phenyl-3H-thieno[2,3-d]pyrimidin-4-one

: 1431470-06-2
N-[2-(5-methyl-4-oxo-6-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylamino)ethyl]-4-(4-methylpiperazin-1-yl)butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 18 h / 130 °C / Sealed tube

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;