(RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

Base Information

Chemical Name:(RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid
CAS No.:1426155-77-2
Molecular Formula:C₁₂H₇F₉O₃
Molecular Weight:370.171
Hs Code.:

Synonyms:(RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

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Chemical Property of (RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

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Technology Process of (RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

There total 3 articles about (RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1426155-80-7
methyl (RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetate

: 1426155-77-2
(RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

Guidance literature:: methyl (RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetate; With sodium hydroxide; In methanol; dichloromethane; at 20 ℃; for 24h;

With hydrogenchloride; In water; at 0 ℃; pH=1;
DOI:10.1016/j.tetlet.2013.01.072

Reference yield:

: 21210-43-5
(S)-Methyl mandelate

: 1426155-77-2
(RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / diethyl ether / 24 h / 0 - 20 °C

2.1: sodium hydroxide / methanol; dichloromethane / 24 h / 20 °C

2.2: 0 °C / pH 1

With di-isopropyl azodicarboxylate; triphenylphosphine; sodium hydroxide; In methanol; diethyl ether; dichloromethane; 1.1: |Mitsunobu Displacement;
DOI:10.1016/j.tetlet.2013.01.072

Reference yield:

: 60633-83-2
methyl (2S)‐2‐[(methylsulfonyl)oxy]‐2‐phenylacetate

: 1426155-77-2
(RS)-2-phenyl-2-[1,1-bis(trifluoromethyl)-2,2,2-trifluoroethoxy]acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dimethyl sulfoxide / 6 h / 80 - 100 °C

2.1: sodium hydroxide / methanol; dichloromethane / 24 h / 20 °C

2.2: 0 °C / pH 1

With sodium hydroxide; In methanol; dichloromethane; dimethyl sulfoxide; 1.1: |Williamson Ether Synthesis;
DOI:10.1016/j.tetlet.2013.01.072