Technology Process of (E)-4-methoxyphenyl 2,3-diphenyl acrylate
There total 7 articles about (E)-4-methoxyphenyl 2,3-diphenyl acrylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-methoxyphenyl formate;
With
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,3,5-trimethyl-benzene;
at 20 ℃;
for 0.25h;
Inert atmosphere;
diphenyl acetylene;
In
1,3,5-trimethyl-benzene;
at 100 ℃;
for 20h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1002/adsc.201000750
- Guidance literature:
-
With
palladium diacetate; potassium carbonate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride;
In
toluene;
at 60 ℃;
for 2h;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.joc.0c02700
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetic anhydride / 20 - 60 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,3,5-trimethyl-benzene / 100 °C / Inert atmosphere
3.1: acetic anhydride / 20 - 60 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
4.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,3,5-trimethyl-benzene / 0.25 h / 20 °C / Inert atmosphere
4.2: 20 h / 100 °C / Inert atmosphere
With
palladium diacetate; acetic anhydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,3,5-trimethyl-benzene;
DOI:10.1002/adsc.201000750
