Phenol, 4-methoxy-, formate

Base Information

• Chemical Name: Phenol, 4-methoxy-, formate
• CAS No.: 4525-64-8
• Molecular Formula: C8H8O3
• Molecular Weight: 152.15
• Mol file: 4525-64-8.mol

Synonyms:

Chemical Property of Phenol, 4-methoxy-, formate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 4-methoxy-, formate

There total 20 articles about Phenol, 4-methoxy-, formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

formic acid (64-18-6) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl formate (4525-64-8)

Guidance literature:

formic acid; With acetic anhydride; at 20 - 60 ℃; Inert atmosphere;

4-methoxy-phenol; With sodium hydrogencarbonate; at 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.201000750

Reference yield: 75.0%

(formyloxy)(acetoxy)phenylmethane (113388-44-6) + 4-methoxy-phenol (150-76-5) → 4-methoxyphenyl formate (4525-64-8)

Guidance literature:

With sodium hydrogencarbonate; In neat (no solvent); at 60 ℃; for 16h;

DOI:10.1016/j.tet.2018.09.014

Reference yield: 58.0%

4-methoxy-benzaldehyde (123-11-5) → 4-methoxyphenyl formate (4525-64-8) + 4-methoxybenzoic acid (100-09-4)

Guidance literature:

With Oxone; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/ol0340078

upstream raw materials:

3,3-dimethyldioxirane

4-methoxy-benzaldehyde

4-methoxy-phenol

formyl acetic anhydride

Downstream raw materials:

(E)-4-methoxyphenyl 2,3-diphenyl acrylate

carbon monoxide

4-methoxy-phenol

4-methoxyphenyl 3-(4-methoxyphenyl)propanoate

Refernces

• 1、 Iron, Mark A.,Khenkin, Alexander M.,Neumann, Ronny,Somekh, Miriam. "The formyloxyl radical: Electrophilicity, C-H bond activation and anti-Markovnikov selectivity in the oxidation of aliphatic alkenes". . p. 11584 - 11591. Retrieved 2020/11/23.
• 2、 Chapman, Robert S.L.,Francis, Molly,Lawrence, Ruth,Tibbetts, Joshua D.,Bull, Steven D.. "Formyloxyacetoxyphenylmethane and 1,1-diacylals as versatile O-formylating and O-acylating reagents for alcohols". . p. 6442 - 6452. Retrieved 2018/10/02.