(S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol

Base Information

Chemical Name:(S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol
CAS No.:852112-77-7
Molecular Formula:C₂₃H₂₁Cl₂FO₃
Molecular Weight:435.322
Hs Code.:

Synonyms:(S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol

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Chemical Property of (S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol

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Technology Process of (S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol

There total 1 articles about (S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 852112-78-8
1-methoxy-2-bromo-4-fluoro-2',6'-dichlorobiphenyl

: 2930-05-4,14618-80-5,89616-40-0,16495-13-9
(S)-benzyl glycidyl ether

: 852112-77-7
(S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol

Guidance literature:: 1-methoxy-2-bromo-4-fluoro-2',6'-dichlorobiphenyl; isopropylmagnesium chloride; In tetrahydrofuran; hexane; at 0 ℃; for 4h;

With copper(I) cyanide; In tetrahydrofuran; hexane; at -30 ℃; for 1h;

(S)-benzyl glycidyl ether; In tetrahydrofuran; hexane; at -30 - 20 ℃; for 12h;

Reference yield: 70.0%

: 852112-77-7
(S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol

: (S)-Acetic acid 1-bromomethyl-2-(5-fluoro-2-hydroxy-phenyl)-ethyl ester

Guidance literature:: (S)-1-Benzyloxy-3-(2',6'-dichloro-5-fluoro-2-methoxybiphenyl-3-yl)propan-2-ol; With hydrogen bromide; In acetic acid; at 70 ℃; for 12h;

With ammonia; In dichloromethane; water;