5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

Base Information

Chemical Name:5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester
CAS No.:917251-17-3
Molecular Formula:C₂₁H₃₄O₄Si
Molecular Weight:378.584
Hs Code.:

5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

Synonyms:5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

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Chemical Property of 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

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Technology Process of 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

There total 7 articles about 5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 623-73-4
diazoacetic acid ethyl ester

: 261917-78-6
(S)-3-((tert-butyldimethylsilyl)oxy)-5-phenylpentanal

: 917251-17-3
5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

Guidance literature:: tin(ll) chloride; In dichloromethane; at 0 - 20 ℃; for 0.666667h;
DOI:10.1016/j.tetlet.2006.09.122

Reference yield:

: 5-(tetrahydro-pyran-2-yloxy)-pent-1-yn-3-ol

: 917251-17-3
5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / Ph₃P; K₂CO₃ / Pd/C; CuI / H₂O; 1,2-dimethoxy-ethane / 2 h / 80 °C

2: 90 percent / Pd/C / ethyl acetate

3: 95 percent / imidazole; DMAP / CH₂Cl₂ / 2 h

4: 90 percent / PPTS / methanol / 12 h

5: 90 percent / IBX; DMSO / CH₂Cl₂ / 2 h

6: 80 percent / SnCl₂ / CH₂Cl₂ / 0.67 h / 0 - 20 °C

With 1H-imidazole; dmap; pyridinium p-toluenesulfonate; potassium carbonate; dimethyl sulfoxide; triphenylphosphine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; copper(l) iodide; tin(ll) chloride; In methanol; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.tetlet.2006.09.122

Reference yield:

: 474944-31-5
(3S)-3-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-5-phenylpentan-1-ol

: 917251-17-3
5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-7-phenyl-heptanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / IBX; DMSO / CH₂Cl₂ / 2 h

2: 80 percent / SnCl₂ / CH₂Cl₂ / 0.67 h / 0 - 20 °C

With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; tin(ll) chloride; In dichloromethane;
DOI:10.1016/j.tetlet.2006.09.122