N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

Base Information

Chemical Name:N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide
CAS No.:1428581-57-0
Molecular Formula:C₂₉H₃₂N₆O₃
Molecular Weight:512.611
Hs Code.:

Synonyms:N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

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Chemical Property of N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

Chemical Property:

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Technology Process of N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

There total 5 articles about N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443004-98-5
N-(1-(1-(4-chloro-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

: 150255-96-2
(3‐cyanophenyl)boronic acid

: 1428581-57-0
N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; at 150 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 3-(2-cyclopropylethyl)-5-methoxybenzoic acid

: 1428581-57-0
N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: dichloromethane / 0.5 h / 20 °C

3.1: diethylamine / acetonitrile / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; acetonitrile / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; diethylamine; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4.1: |Suzuki-Miyaura Coupling;

Reference yield:

: 455267-29-5
4-(1-amino-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1428581-57-0
N-(1-(1-(4-(3-cyanophenyl)-1,3,5-triazin-2-yl)piperidin-4-yl)ethyl)-3-(cyclopropylmethoxy)-5-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 2 h / 20 °C

2.1: dichloromethane / 0.5 h / 20 °C

3.1: diethylamine / acetonitrile / 0.17 h / 20 °C

3.2: 1 h / 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; acetonitrile / 0.17 h / 150 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; diethylamine; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 4.1: |Suzuki-Miyaura Coupling;