2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Base Information

Chemical Name:2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile
CAS No.:1350730-01-6
Molecular Formula:C₂₁H₁₈FN₅O₂
Molecular Weight:391.405
Hs Code.:

Synonyms:2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Suppliers and Price of 2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

There total 4 articles about 2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1350660-03-5
4-[3-(2-chloro-pyrimidin-5-yloxy)phenyl]morpholine

: 53312-81-5
3-cyano-4-fluoroaniline

: 1350730-01-6
2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 48h;

Reference yield:

: 863377-22-4
[3-(morpholine-4-yl)phenyl]boronic acid

: 1350730-01-6
2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper diacetate / dichloromethane / 72 h / Molecular sieve; Air conditions

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 80 °C

With copper diacetate; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

Reference yield:

: 197846-82-5
1-(3-bromophenyl)-morpholine

: 1350730-01-6
2-fluoro-5-[5-(3-morpholin-4-ylphenoxy)-pyrimidin-2-ylamino]-benzo-nitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 - -70 °C

1.2: 20 °C / Cooling with acetone-dry ice

2.1: triethylamine; copper diacetate / dichloromethane / 72 h / Molecular sieve; Air conditions

3.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 48 h / 80 °C

With n-butyllithium; copper diacetate; caesium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;