5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

Base Information

Chemical Name:5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester
CAS No.:173606-90-1
Molecular Formula:C₂₇H₃₀N₁₁O₁₂P
Molecular Weight:731.575
Hs Code.:

Synonyms:5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

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Chemical Property of 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

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Technology Process of 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

There total 6 articles about 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3958-57-4
1-bromomethyl-3-nitrobenzene

: 5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl) phosphate tetra-n-butylammonium salt

: 173606-90-1
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

Guidance literature:: In acetonitrile; at 85 ℃; for 8h;

Reference yield:

: 166318-79-2
1-Hydroxy-1-(3-nitrophenyl)methylphosphonate 5',5'-di-O-(3'-azido-2',3'-dideoxythymidinyl) ester

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 124930-59-2
3'-azido-3'-deoxythymidin-5'-yl H-phosphonate monoester

: 173606-90-1
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

Guidance literature:: With phosphate buffer; at 37 ℃; pH: 7.5; half-lives determination; also in FCS (fetal calf serum) containing RPMI (Roswell Park Memorial Institute) culture medium;

Reference yield:

: 30516-87-1,399024-19-2
3'-azido-2',3'-deoxythymidine

: 173606-90-1
5',5'-Di-O-(3'-azido-2',3'-dideoxythymidinyl)-O'-(3-nitrobenzyl) phosphotriester

Guidance literature:: Multi-step reaction with 5 steps

1: DIPEA / acetonitrile / 0.25 h / 0 °C

2: 1.) 1H-tetrazole, 2.) H₂O / 1.) CH₃CN, 0 deg C, 30 min, 2.) 25 deg C, 45 min

3: I₂, H₂O, pyridine / 0.25 h / 25 °C

5: 95 percent / acetonitrile / 8 h / 85 °C

With pyridine; 1H-tetrazole; water; iodine; N-ethyl-N,N-diisopropylamine; In acetonitrile;