4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

Base Information

Chemical Name:4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol
CAS No.:916728-17-1
Molecular Formula:C₂₇H₃₇NO₆
Molecular Weight:471.594
Hs Code.:

Synonyms:4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

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Chemical Property of 4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

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Technology Process of 4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

There total 4 articles about 4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 916728-16-0
7-(4-methoxy-benzyl)-6-[4-(4-methoxy-benzyloxy)-butyl]-2,2-dimethyl-9-vinyl-1,3,8-trioxa-7-aza-spiro[4.5]decane

: 916728-17-1
4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 48h;
DOI:10.1002/anie.200602569

Reference yield:

: 916728-14-8
2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinane-4-carboxylic acid methyl ester

: 916728-17-1
4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / KHMDS; 3-phenyl-2-(p-toluenesulfonyl)-oxaziridine / tetrahydrofuran / 2.5 h / cooling

2: 97 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 2 h / cooling

3: p-toluenesulfonic acid / dimethylsulfoxide / 48 h / 20 °C

4: 93 percent / aq. HCl / tetrahydrofuran / 48 h

With hydrogenchloride; lithium aluminium tetrahydride; potassium hexamethylsilazane; toluene-4-sulfonic acid; 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;
DOI:10.1002/anie.200602569

Reference yield:

: 4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

: 916728-17-1
4-hydroxymethyl-2-(4-methoxy-benzyl)-3-[4-(4-methoxy-benzyloxy)-butyl]-6-vinyl-[1,2]oxazinan-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / dimethylsulfoxide / 48 h / 20 °C

2: 93 percent / aq. HCl / tetrahydrofuran / 48 h

With hydrogenchloride; toluene-4-sulfonic acid; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/anie.200602569