ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate

Base Information

• Chemical Name: ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate
• CAS No.: 1296794-74-5
• Molecular Formula: C₄₅H₆₄N₂O₅S
• Molecular Weight: 745.08
• Mol file: 1296794-74-5.mol

Synonyms:ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate

Chemical Property of ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate

There total 5 articles about ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 16-aminohexadecanoate + N-tert-butyloxycarbonyl-S-trityl-L-cysteine (21947-98-8,87494-13-1) → ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate (1296794-74-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/jlcr.1836

Reference yield:

C16H33NO2*ClH (110504-18-2) → ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate (1296794-74-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1002/jlcr.1836

Reference yield:

ethyl 16-phthalimidohexadecanoate → ethyl 16-(N-Boc-S-trityl-cysteinylamido)hexadecanoate (1296794-74-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrazine hydrate / ethanol / 3 h / Reflux

1.2: Reflux

2.1: sulfuric acid / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

With sulfuric acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;

DOI:10.1002/jlcr.1836

upstream raw materials:

C₁₆H₃₃NO₂*ClH

N-tert-butyloxycarbonyl-S-trityl-L-cysteine

16-bromohexadecanoic acid

ethyl 16-bromohexadecanoate

Downstream raw materials:

16-(N-Boc-S-trityl-cysteinylamido)hexadecanoic acid