N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide
CAS No.:1439877-26-5
Molecular Formula:C₂₉H₂₅F₃N₄O₅
Molecular Weight:566.537
Hs Code.:

Synonyms:N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

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Chemical Property of N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

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Technology Process of N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

There total 13 articles about N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.4%

: 1439878-89-3
N-(4-((2-chloropyridin-4-yl)oxy)-2,5-difluorophenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

: 79-05-0
Propionamid

: 1439877-26-5
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 90 ℃; Inert atmosphere; Sonication;

Reference yield:

: 17368-12-6
2-chloropyridin-4-ol

: 1439877-26-5
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 15 - 25 °C

1.2: 1.17 h

2.1: hydrogen / methanol / 4 h / 517.16 - 1034.32 Torr

3.1: triethylamine / tetrahydrofuran / 15 - 25 °C

4.1: potassium carbonate / 0.67 h / 120 °C / Microwave irradiation

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C / Inert atmosphere; Sonication

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen; potassium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 1439877-26-5
N-(2,5-difluoro-4-((2-propionamidopyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-isopropoxy-2-oxo-1,2-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: acetic acid / 120 - 130 °C

2: 2 h / 70 °C

3: acetic acid / Reflux

4: copper diacetate; pyridine / dichloromethane / 4 h / 15 - 25 °C

5: lithium hydroxide; water / ethanol / 16 h / 15 - 25 °C

6: thionyl chloride; N,N-dimethyl-formamide / toluene / 2 h / Reflux

7: triethylamine / tetrahydrofuran / 15 - 25 °C

8: potassium carbonate / 0.67 h / 120 °C / Microwave irradiation

9: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 90 °C / Inert atmosphere; Sonication

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; water; copper diacetate; potassium carbonate; caesium carbonate; acetic acid; triethylamine; N,N-dimethyl-formamide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;