Propionamide

Base Information

• Chemical Name: Propionamide
• CAS No.: 79-05-0
• Molecular Formula: C3H7NO
• Molecular Weight: 73.0947
• Hs Code.: 29241900
• European Community (EC) Number: 201-172-1
• NSC Number: 38708
• UNII: QK07G0HP47
• DSSTox Substance ID: DTXSID3058820
• Nikkaji Number: J22.070A
• Wikipedia: Propanamide
• Wikidata: Q3082378
• Metabolomics Workbench ID: 56614
• ChEMBL ID: CHEMBL1235716
• Mol file: 79-05-0.mol

Synonyms:Propionamide(6CI,8CI);NSC 38708;Propanimidic acid;Propionic acid amide;Propionic amide;

Chemical Property of Propionamide

Chemical Property:

• Appearance/Colour: white to slightly yellow crystalline powder
• Vapor Pressure: 0.103mmHg at 25°C
• Melting Point: 79 °C
• Refractive Index: 1.409
• Boiling Point: 222.2 °C at 760 mmHg
• PKA: 16.60±0.40(Predicted)
• Flash Point: 84.9 °C
• PSA: 43.09000
• Density: 0.926 g/cm³
• LogP: 0.58200
• Storage Temp.: Store below +30°C.
• Solubility.: SOLUBLE
• Water Solubility.: SOLUBLE
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 73.052763847
• Heavy Atom Count: 5
• Complexity: 42.2

Purity/Quality:

99.9% ^*data from raw suppliers

Propionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 24/25-36/37/39-26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Amides (
• Canonical SMILES: CCC(=O)N
• Uses: Propionamide was used as adsorbent in the determination of adsorption isotherms of acetamide and propionamide on multi-wall carbon nanotube. It was used in a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.

Technology Process of Propionamide

There total 85 articles about Propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

propionic acid 2-phenylhydrazide (20730-02-3) → aniline (62-53-3) + Propionamid (79-05-0)

Guidance literature:

With hydrogen; palladium; In ethanol; acetic acid; under 2585.7 Torr;

Reference yield: 24.2%

propiononitrile (107-12-0) → calcium propionate (4075-81-4) + Propionamid (79-05-0)

Guidance literature:

With calcium hydroxide; water; at 160 - 200 ℃; for 2.66 - 12.33h; under 516.802 - 13445.8 Torr; Conversion of starting material;

Reference yield:

2-methyl-N-propionylpropionamide (97119-10-3) + phenyllithium (591-51-5) → ISOPROPYLAMIDE (563-83-7) + 1-phenyl-propan-1-one (93-55-0) + phenyl isopropyl ketone (611-70-1) + Propionamid (79-05-0)

Guidance literature:

In diethyl ether; at -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

diazoacetone

1-thiopropane

propene

propyl sulfide

Downstream raw materials:

N-(2-[4]pyridyl-ethyl)-propionamide

6-ethylbenzimidazo<1,2-c>quinazoline

N-trityl-propionamide

N-(4-hydroxy-benzylidene)-propionamide

Refernces

• 1、 Kuroda et al.. "". . p. 2371,2372,2373,2374. Retrieved 1972.
• 2、 Babón, Juan C.,Esteruelas, Miguel A.,López, Ana M.,O?ate, Enrique. "Hydration of Aliphatic Nitriles Catalyzed by an Osmium Polyhydride: Evidence for an Alternative Mechanism". . p. 7284 - 7296. Retrieved 2021/05/29.
• 3、 Nielsen, John,Tung, Truong Thanh. "Amide bond formation in aqueous solution: Direct coupling of metal carboxylate salts with ammonium salts at room temperature". supporting information. p. 10073 - 10080. Retrieved 2021/12/10.