Propionamide

Base Information

• Chemical Name: Propionamide
• CAS No.: 79-05-0
• Molecular Formula: C3H7NO
• Molecular Weight: 73.0947
• Hs Code.: 29241900
• European Community (EC) Number: 201-172-1
• NSC Number: 38708
• UNII: QK07G0HP47
• DSSTox Substance ID: DTXSID3058820
• Nikkaji Number: J22.070A
• Wikipedia: Propanamide
• Wikidata: Q3082378
• Metabolomics Workbench ID: 56614
• ChEMBL ID: CHEMBL1235716
• Mol file: 79-05-0.mol

Synonyms:Propionamide(6CI,8CI);NSC 38708;Propanimidic acid;Propionic acid amide;Propionic amide;

Chemical Property of Propionamide

Chemical Property:

• Appearance/Colour: white to slightly yellow crystalline powder
• Vapor Pressure: 0.103mmHg at 25°C
• Melting Point: 79 °C
• Refractive Index: 1.409
• Boiling Point: 222.2 °C at 760 mmHg
• PKA: 16.60±0.40(Predicted)
• Flash Point: 84.9 °C
• PSA: 43.09000
• Density: 0.926 g/cm³
• LogP: 0.58200
• Storage Temp.: Store below +30°C.
• Solubility.: SOLUBLE
• Water Solubility.: SOLUBLE
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 73.052763847
• Heavy Atom Count: 5
• Complexity: 42.2

Purity/Quality:

99.9% ^*data from raw suppliers

Propionamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 24/25-36/37/39-26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Amides (
• Canonical SMILES: CCC(=O)N
• Uses: Propionamide was used as adsorbent in the determination of adsorption isotherms of acetamide and propionamide on multi-wall carbon nanotube. It was used in a robust screening method to study biotransformations using (+)-γ-lactamase enzyme.

Technology Process of Propionamide

There total 85 articles about Propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

propionic acid 2-phenylhydrazide (20730-02-3) → aniline (62-53-3) + Propionamid (79-05-0)

Guidance literature:

With hydrogen; palladium; In ethanol; acetic acid; under 2585.7 Torr;

Reference yield: 24.2%

propiononitrile (107-12-0) → calcium propionate (4075-81-4) + Propionamid (79-05-0)

Guidance literature:

With calcium hydroxide; water; at 160 - 200 ℃; for 2.66 - 12.33h; under 516.802 - 13445.8 Torr; Conversion of starting material;

Reference yield:

2-methyl-N-propionylpropionamide (97119-10-3) + phenyllithium (591-51-5) → ISOPROPYLAMIDE (563-83-7) + 1-phenyl-propan-1-one (93-55-0) + phenyl isopropyl ketone (611-70-1) + Propionamid (79-05-0)

Guidance literature:

In diethyl ether; at -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

upstream raw materials:

diazoacetone

1-thiopropane

propene

propyl sulfide

Downstream raw materials:

N-xanthen-9-yl-propionamide

N-(2-[4]pyridyl-ethyl)-propionamide

6-ethylbenzimidazo<1,2-c>quinazoline

Hexahydro-1,3,5-trinitro-1,3,5-triazine

Refernces

Novel inhibitors of influenza sialidase related to GG167. Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase

10.1016/0960-894X(96)00318-6

The study focuses on the synthesis and evaluation of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides as selective inhibitors of influenza A virus sialidase. The researchers synthesized these compounds from 2,3-didehydro-2,4-dideoxy-4-amino-N-acetylneuraminic acid (4) and found that the propylamides, particularly the dipropylamides (3a and 3b), exhibited high potency and selectivity against influenza A sialidase compared to the related inhibitors GG167 and 4. The study demonstrated that the 6-dipropylcarboxamide substituent is preferable to the polar glycerol sidechain found in GG167 for inhibiting influenza A sialidase. The synthesized propylamides showed significant inhibitory activity in both sialidase inhibition and in vitro antiviral assays, highlighting their potential as effective inhibitors for influenza A treatment.