1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Base Information

• Chemical Name: 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene
• CAS No.: 691881-06-8
• Molecular Formula: C₁₈H₂₃BrN₂O₃S
• Molecular Weight: 427.362
• Mol file: 691881-06-8.mol

Synonyms:1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Chemical Property of 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

There total 4 articles about 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-(methylthio)phenyl)acetic acid (16188-55-9) → 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene (691881-06-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 100 percent / H₂SO₄ / 16 h / 50 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

2.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

3.1: 46 percent / glacial AcOH / 1 h / 100 °C

4.1: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

5.1: 93 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 72 h / 20 °C

With oxone; carbon tetrabromide; sulfuric acid; acetic acid; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2004.01.012

Reference yield:

(4-methylsulfanyl-phenyl)-acetic acid methyl ester (70290-37-8) → 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene (691881-06-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

2.1: 46 percent / glacial AcOH / 1 h / 100 °C

3.1: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

4.1: 93 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 72 h / 20 °C

With oxone; carbon tetrabromide; acetic acid; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2004.01.012

Reference yield:

methyl 3-cyclohexyl-2-(4-methylthiophenyl)-3-oxo-propanoate (691881-03-5) → 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene (691881-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / glacial AcOH / 1 h / 100 °C

2: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

3: 93 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 72 h / 20 °C

With oxone; carbon tetrabromide; acetic acid; triphenylphosphine; In methanol; dichloromethane; water;

DOI:10.1016/j.bmc.2004.01.012

upstream raw materials:

2-(4-(methylthio)phenyl)acetic acid

(4-methylsulfanyl-phenyl)-acetic acid methyl ester

methyl 3-cyclohexyl-2-(4-methylthiophenyl)-3-oxo-propanoate

3-cyclohexyl-1-(2-hydroxyethyl)-4-(4-methylthiophenyl)pyrazol-5-ol