1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Base Information

Chemical Name:1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene
CAS No.:691881-06-8
Molecular Formula:C₁₈H₂₃BrN₂O₃S
Molecular Weight:427.362
Hs Code.:

Synonyms:1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

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Chemical Property of 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

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Technology Process of 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

There total 4 articles about 1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16188-55-9
2-(4-(methylthio)phenyl)acetic acid

: 691881-06-8
1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / H₂SO₄ / 16 h / 50 °C

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

2.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

3.1: 46 percent / glacial AcOH / 1 h / 100 °C

4.1: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

5.1: 93 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 72 h / 20 °C

With oxone; carbon tetrabromide; sulfuric acid; acetic acid; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 70290-37-8
(4-methylsulfanyl-phenyl)-acetic acid methyl ester

: 691881-06-8
1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 99 percent / tetrahydrofuran / 2 h / -78 - 0 °C

2.1: 46 percent / glacial AcOH / 1 h / 100 °C

3.1: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

4.1: 93 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 72 h / 20 °C

With oxone; carbon tetrabromide; acetic acid; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2004.01.012

Reference yield:

: 691881-03-5
methyl 3-cyclohexyl-2-(4-methylthiophenyl)-3-oxo-propanoate

: 691881-06-8
1-[1-(2-bromoethyl)-3-cyclohexyl-5-hydroxypyrazol-4-yl]-4-(methylsulfonyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / glacial AcOH / 1 h / 100 °C

2: 43 percent / Oxone(R) / methanol; H₂O / 0.5 h / 20 °C

3: 93 percent / carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 72 h / 20 °C

With oxone; carbon tetrabromide; acetic acid; triphenylphosphine; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2004.01.012