4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate
CAS No.:1520080-23-2
Molecular Formula:C₁₅H₂₂F₃NO₆SSi
Molecular Weight:429.489
Hs Code.:

Synonyms:4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

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Chemical Property of 4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

There total 3 articles about 4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 456-64-4
phenyl trifluoromethanesulfonamide

: 1520080-36-7
methyl 2-hydroxy-5-methoxy-3-(trimethylsilyl)benzyl(methyl)carbamate

: 1520080-23-2
4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol403142d

Reference yield:

: 672-13-9
2-hydroxy-5-methoxybenzaldehyde

: 1520080-23-2
4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 1 h / 20 °C

1.2: 0.5 h / 0 - 20 °C

2.1: tetrahydrofuran; acetone; water / 2 h / 0 - 20 °C

3.1: tetra-N-butylammonium tribromide / methanol; dichloromethane / 1 h / 0 - 20 °C

4.1: triethylamine / dichloromethane-d2 / 0 - 20 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; tetra-N-butylammonium tribromide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dichloromethane-d2; water; acetone; mineral oil;
DOI:10.1021/ol403142d

Reference yield:

: 937685-04-6
C₉H₁₃NO₂

: 1520080-23-2
4-methoxy-2-(((methoxycarbonyl)(methyl)amino)methyl)-6-(trimethylsilyl)-phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran; acetone; water / 2 h / 0 - 20 °C

2: tetra-N-butylammonium tribromide / methanol; dichloromethane / 1 h / 0 - 20 °C

3: triethylamine / dichloromethane-d2 / 0 - 20 °C / Inert atmosphere

4: n-butyllithium / tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

5: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

With n-butyllithium; tetra-N-butylammonium tribromide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dichloromethane-d2; water; acetone; mineral oil;
DOI:10.1021/ol403142d