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456-64-4

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456-64-4 Usage

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 3839, 1973 DOI: 10.1016/S0040-4039(01)87051-9

Check Digit Verification of cas no

The CAS Registry Mumber 456-64-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 456-64:
(5*4)+(4*5)+(3*6)+(2*6)+(1*4)=74
74 % 10 = 4
So 456-64-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H6F3NO2S/c8-7(9,10)14(12,13)11-6-4-2-1-3-5-6/h1-5,11H

456-64-4 Well-known Company Product Price

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  • TCI America

  • (T2985)  Trifluoromethanesulfonanilide  >98.0%(HPLC)(T)

  • 456-64-4

  • 1g

  • 990.00CNY

  • Detail
  • TCI America

  • (T2985)  Trifluoromethanesulfonanilide  >98.0%(HPLC)(T)

  • 456-64-4

  • 5g

  • 3,650.00CNY

  • Detail

456-64-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,1,1-Trifluoro-N-phenylmethanesulfonamide

1.2 Other means of identification

Product number -
Other names N-Phenyl(trifluoromethane)sulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:456-64-4 SDS

456-64-4Relevant academic research and scientific papers

Asymmetric synthesis of the fully functionalized six-membered ring of trigoxyphin A

Feng, Jing,Yu, Tianzi,Zhang, Zhijiang,Li, Jinpeng,Fu, Shaomin,Chen, Juan,Liu, Bo

, p. 7665 - 7668 (2018)

An asymmetric synthesis strategy of the fully functionalized six-membered ring of trigoxyphin A, a daphnane-type diterpenoid, has been accomplished concisely from a d-tartrate derivative. Key elements of this synthesis involve the tandem ozonization/intramolecular HWE reaction to construct the α,β-unsaturated cyclohexenone skeleton, the radical cyclization to introduce the C8 chirality and sequential Kumada cross-coupling/hydroboration-oxidation to introduce the C11 chirality. The target substructure could be synthetically achieved on a multi-gram scale.

Preparation and Application of Amino Phosphine Ligands Bearing Spiro[indane-1,2′-pyrrolidine] Backbone

Feng, Lifei,Jiao, Peng,Li, Hongjie,Li, Shasha,Zhang, Jinxia

, p. 9460 - 9473 (2019/08/26)

P,Nsp3-bidentate chiral ligands bearing spiro[indane-1,2′-pyrrolidine] backbone were prepared in gram scale for the first time. Pd complexes of these air-stable amino phosphine ligands could catalyze asymmetric allylic substitutions of malonate-, alcohol-, and amine-type nucleophiles in up to 97percent ee and 99percent yield. A crystal structure of [Pd(II)(η3-1,3-diphenylallyl)(ligand)]PF6 indicated possible transition states of the catalytic reactions. These ligands are characteristic of a very rigid backbone, which is simple but highly effective. They rival C2-symmetric bisphosphine, P,Nsp2-bidentate, and P,Nsp3-bidentate ligands in tested allylic substitutions. ?

N-triflyl-propiolamides: Preparation and transamidation reactions

Fiore, Vito A.,Maas, Gerhard

, p. 3586 - 3595 (2019/05/27)

N-Trifluoromethylsulfonyl-propiolamides have been prepared by two methods: a) N-triflation of secondary acetylenic carboxanilides, prepared in two steps from terminal alkynes, with triflic anhydride (Tf2O) and b) from terminal alkynes and an aryl or alkyl isocyanate followed by Tf2O in a consecutive one-pot reaction. The title compounds are bench-stable and insensitive to water and alcohols but amenable to transamidation reactions with a wide range of amine nucleophiles. Conversely, they are excellent reagents for the propynoylation of ammonia, primary and secondary amines, anilines, and hydrazines.

Sulfoxide ligand metal catalyzed oxidation of olefins

-

Page/Page column 118-119, (2019/05/09)

The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp3)-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

Selective cleavage of the N-propargyl group from sulfonamides and amides under ruthenium catalysis

Wang, Jingjing,Li, Feng,Pei, Wenlong,Yang, Mixue,Wu, Yidan,Ma, Danyang,Zhang, Furong,Wang, Jianhui

supporting information, p. 1902 - 1905 (2018/04/19)

The selective cleavage of the N-propargyl group from sulfonamides and amides under ruthenium catalysis is described. The reaction tolerates a broad range of functional groups, and the desired products were obtained in 10–95% yield.

SUBSTITUTED PYRROLO[2,3-B]-PYRIDINES AND-PYRAZINES

-

Page/Page column 47, (2010/07/10)

Compounds of Formula I, as shown below and defined herein:(I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by Ron and/or Met.

DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE

-

Page/Page column 33-34, (2009/07/18)

The present invention is related to a compound of formula (I): wherein i, j, n, o, p, q, r, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b and R4 are as defined herein, or an addition salt with an acid thereof, or a hydrate or solvate thereof, its preparation, pharmaceutical composition, and uses for treating a disease in which the enzyme 11β-HSD1 is involved.

Triflamides and triflates of six-membered heterocyclic amines

Shainyan,Tolstikov,Zhinkin

, p. 1180 - 1182 (2007/10/03)

Reactions of secondary cyclic amines (piperidine, morpholine, thiomorpholine, 1λ6,4-thiazinane-1,1-dione) with trifluoromethanesulfonic anhydride or with N-phenyltriflimide both in the presence and in the absence of a base (Et3N) result in formation of corresponding triflamides and triflates of the initial amines. The triflates and triflamides can be distinguished by their 19F and 15N NMR spectra and the presence in the IR spectra of salts of absorption bands in the region 3270-3000 cm-1 lacking in the spectra of triflamides.

SYNTHESIS OF PYRIMIDINYL TRIFLATES AND PALLADIUM-CATALYZED COUPLING WITH ORGANOTIN AND ORGANOZINC REAGENTS

Sandosham, Jessie,Undheim, Kjell

, p. 501 - 514 (2007/10/02)

Pyrimidinyl triflates have been synthesized from pyrimidinones using triflic anhydride in the presence of triethylamine.The triflates, in the pyrimidine electrophilic positions, are versatile intermediates for substitution reactions.Carbon substituents ar

Electrophilic fluorination of aromatic compounds

-

, (2008/06/13)

A process for the electrophilic ring fluorination of aromatic compounds which comprises reacting a fluorinating agent from the group consisting of CF3 OF and CF2 (OF)2 with an aromatic compound of the formula STR1 where X is selected from the group consisting of STR2 and STR3 and Y is selected from the group consisting of --H, --CF3, --CN, --NO2, --Cl, and CH3.

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