2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

Base Information

Chemical Name:2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol
CAS No.:236752-38-8
Molecular Formula:C₄₇H₄₃NO₆
Molecular Weight:717.862
Hs Code.:

Synonyms:2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

Chemical Property:

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Technology Process of 2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

There total 5 articles about 2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 136918-14-4,85-41-6
phthalimide

: 236752-35-5
2,2-bis(benzyloxymethyl)-3-(4-monomethoxytrityloxy)propanediol

: 236752-38-8
2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1016/S0040-4020(99)00378-6

Reference yield:

: 2997-97-9
2,2-bis{(benzyloxy)methyl}propane-1,3-diol

: 236752-38-8
2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / pyridine

2: 88 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; 1: Alkylation / 2: Addition;
DOI:10.1016/S0040-4020(99)00378-6

Reference yield:

: 100-39-0
benzyl bromide

: 236752-38-8
2,2-bis(benzyloxymethyl)-1-(4-monomethoxytrityloxy)-3-phthalimidopropanol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / sodium hydride / tetrahydrofuran / 48 h

2: 51 percent / hydrochloric acid / H₂O; dioxane / 8 h

3: 67 percent / pyridine

4: 88 percent / diethyl azodicarboxylate; triphenylphosphine / tetrahydrofuran

With hydrogenchloride; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; pyridine; water; 1: Alkylation / 2: Hydrolysis / 3: Alkylation / 4: Addition;
DOI:10.1016/S0040-4020(99)00378-6