C₂₆H₂₆N₂O₃

Base Information

• Chemical Name: C₂₆H₂₆N₂O₃
• CAS No.: 129708-79-8
• Molecular Formula: C₂₆H₂₆N₂O₃
• Molecular Weight: 414.504

Synonyms:C₂₆H₂₆N₂O₃

Chemical Property of C₂₆H₂₆N₂O₃

Chemical Property:

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Technology Process of C₂₆H₂₆N₂O₃

There total 13 articles about C₂₆H₂₆N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(E)-(2S,6R,12bR)-(+)-methyl 12-benzyl-13-oxo-1,2,3,4,5,6,7,12,12b-octahydro-2,6-methanoindolo<2,3-a>quinolizine-3-ethylidenoate (119184-29-1,119241-72-4) → C26H26N2O3 (129708-79-8)

Guidance literature:

With copper diacetate; diiodomethane; titanium tetrachloride; acetic acid; zinc; In tetrahydrofuran; dichloromethane; for 16h; Ambient temperature;

DOI:10.1021/ja00169a033

Reference yield:

(S)-3-(1-Benzyl-1H-indol-3-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester (129708-73-2) → C26H26N2O3 (129708-79-8)

Guidance literature:

Multi-step reaction with 12 steps

1: 95 percent / sodium borohydride / methanol / 1 h / 25 °C

2: 67 percent / benzene; dioxane / 24 h / Heating

3: chlorotrimethylsilane / 25 °C

4: 72 percent / NaH, MeOH / toluene / 16 h / Heating

5: 99 percent / HOAc, H₂SO₄ / H₂O / 72 h / Heating

6: 85 percent / 88percent aq. formic acid / 10percent Pd/C / 2 h / Ambient temperature

7: 60 percent / K₂CO₃ / ethanol; toluene / 12 h / Ambient temperature

8: 82 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

9: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) from -78 deg C to -30 deg C

10: 91 percent / lithium tetrafluoroborate / tetrahydrofuran; acetonitrile / 72 h / Heating

11: 71 percent / pyrrolidine, trifluoroacetic acid / benzene / 19 h / Heating

12: 74 percent / Zn, Cu(OAc)2, CH₂I₂, TiCl₄, glacial acetic acid / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With pyrrolidine; methanol; sodium tetrahydroborate; lithium tetrafluoroborate; n-butyllithium; chloro-trimethyl-silane; formic acid; copper diacetate; diiodomethane; sulfuric acid; titanium tetrachloride; sodium hydride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; benzene;

DOI:10.1021/ja00169a033

Reference yield:

(6R,10R)-(+)-5,12-dibenzyl-9-oxo-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooctindole (129708-76-5) → C26H26N2O3 (129708-79-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / 88percent aq. formic acid / 10percent Pd/C / 2 h / Ambient temperature

2: 60 percent / K₂CO₃ / ethanol; toluene / 12 h / Ambient temperature

3: 82 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 15 min, 2.) from -78 deg C to -30 deg C

5: 91 percent / lithium tetrafluoroborate / tetrahydrofuran; acetonitrile / 72 h / Heating

6: 71 percent / pyrrolidine, trifluoroacetic acid / benzene / 19 h / Heating

7: 74 percent / Zn, Cu(OAc)2, CH₂I₂, TiCl₄, glacial acetic acid / tetrahydrofuran; CH₂Cl₂ / 16 h / Ambient temperature

With pyrrolidine; lithium tetrafluoroborate; n-butyllithium; formic acid; copper diacetate; diiodomethane; titanium tetrachloride; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile; benzene;

DOI:10.1021/ja00169a033

upstream raw materials:

(E)-(2S,6R,12bR)-(+)-methyl 12-benzyl-13-oxo-1,2,3,4,5,6,7,12,12b-octahydro-2,6-methanoindolo<2,3-a>quinolizine-3-ethylidenoate

(6R,10R)-(+)-5-benzyl-9-oxo-12-(prop-2-ynyl)-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooctindole

(S)-3-(1-Benzyl-1H-indol-3-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester

(6R,10R)-(+)-5,12-dibenzyl-9-oxo-6,7,8,9,10,11-hexahydro-6,10-imino-5H-cyclooctindole

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