(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

Base Information

Chemical Name:(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate
CAS No.:148016-90-4
Molecular Formula:C₃₄H₃₅NO₆S₂
Molecular Weight:617.787
Hs Code.:

Synonyms:(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

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Technology Process of (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

There total 6 articles about (2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

: 124-63-0
methanesulfonyl chloride

: 148016-89-1
(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol

: 148016-90-4
(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at -30 ℃; for 0.333333h;
DOI:10.7164/antibiotics.49.199

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 148016-90-4
(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 32.48 g / triethylamine / methanol / 0.33 h

2: 98 percent / triethylamine / CH₂Cl₂ / 0.25 h / -30 °C

3: 1) sodium hydride / 1) DMF, room temperature, 1 h, 2) 60 deg C, 30 min

4: 68 percent / LiBH₄ / tetrahydrofuran / 0.5 h / 60 °C

5: 87.4 percent / triethylamine / CH₂Cl₂ / 0.33 h / -30 °C

With lithium borohydride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.7164/antibiotics.49.199

Reference yield:

: 104773-44-6
(2S,4R)-1-p-methoxybenzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester

: 148016-90-4
(2S,4S)-1-p-methoxybenzyloxycarbonyl-4-tritylthiopyrrolidine-2-methanol methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / triethylamine / CH₂Cl₂ / 0.25 h / -30 °C

2: 1) sodium hydride / 1) DMF, room temperature, 1 h, 2) 60 deg C, 30 min

3: 68 percent / LiBH₄ / tetrahydrofuran / 0.5 h / 60 °C

4: 87.4 percent / triethylamine / CH₂Cl₂ / 0.33 h / -30 °C

With lithium borohydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.7164/antibiotics.49.199