pyridazine-4-boronic acid pinacol ester

Base Information

• Chemical Name: pyridazine-4-boronic acid pinacol ester
• CAS No.: 863422-41-7
• Molecular Formula: C₁₀H₁₅BN₂O₂
• Molecular Weight: 206.052
• Mol file: 863422-41-7.mol

Synonyms:4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridazine;Pyridazine-4-boronic acid pinacol ester;

Chemical Property of pyridazine-4-boronic acid pinacol ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.488
• Boiling Point: 347.617 °C at 760 mmHg
• PKA: 2.63±0.10(Predicted)
• Flash Point: 164.033 °C
• PSA: 44.24000
• Density: 1.078 g/cm³
• LogP: 0.77580

Purity/Quality:

97% ^*data from raw suppliers

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of pyridazine-4-boronic acid pinacol ester

There total 1 articles about pyridazine-4-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

s-Tetrazine (290-96-0) + 2-ethynyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (347389-74-6) → 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridazine (863422-41-7)

Guidance literature:

In nitrobenzene; at 140 ℃; for 6h;

DOI:10.1002/anie.200500288

Reference yield: 2.0%

4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridazine (863422-41-7) + (Z)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-bromoacrylamide (1642300-95-5) → (E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyridazin-4-yl)acrylamide

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; water; at 20 - 100 ℃; for 12h; Inert atmosphere;

upstream raw materials:

s-Tetrazine

2-ethynyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane