N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

Base Information

Chemical Name:N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate
CAS No.:1378379-91-9
Molecular Formula:C₂HF₃O₂*C₁₉H₂₅N₃OS
Molecular Weight:457.517
Hs Code.:

Synonyms:N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

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Chemical Property of N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

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Technology Process of N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

There total 4 articles about N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 3622-35-3
benzothiazole-6-carboxylic acid

: 76-05-1
trifluoroacetic acid

: 259538-87-9
((R)-1-cyclohexylpyrrolidin-2-yl)methanamine

: 1378379-91-9
N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

Guidance literature:: benzothiazole-6-carboxylic acid; ((R)-1-cyclohexylpyrrolidin-2-yl)methanamine; With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 14h; Inert atmosphere;

trifluoroacetic acid; In water;
DOI:10.1021/jm300030r

Reference yield:

: 1378377-91-3
(R)-methyl 1-cyclohexylpyrrolidine-2-carboxylate

: 1378379-91-9
N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / tetrahydrofuran; water / 14 h / 60 °C / Inert atmosphere

2: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 0 - 20 °C / Inert atmosphere

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 25 °C / Inert atmosphere

With 4-methyl-morpholine; lithium aluminium tetrahydride; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1021/jm300030r

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1378379-91-9
N-(((R)-1-cyclohexylpyrrolidin-2-yl)methyl)benzo[d]thiazole-6-carboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / methanol / 0.08 h / Molecular sieve; Inert atmosphere

1.2: 1.5 h

2.1: ammonia / tetrahydrofuran; water / 14 h / 60 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether / 1.5 h / 0 - 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 14 h / 25 °C / Inert atmosphere

With 4-methyl-morpholine; lithium aluminium tetrahydride; ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jm300030r