(S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

Base Information

Chemical Name:(S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid
CAS No.:1333115-59-5
Molecular Formula:C₂₅H₃₁F₃N₂O₇S
Molecular Weight:560.592
Hs Code.:

Synonyms:(S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

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Chemical Property of (S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

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Technology Process of (S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

There total 10 articles about (S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1333115-58-4
(S)-ethyl 2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate

: 1333115-59-5
(S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

Guidance literature:: (S)-ethyl 2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetate; With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1333115-59-5
(S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol

4.1: triethylamine / dichloromethane / 12 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

7.1: triethylamine / dmap / dichloromethane / 12 h / 20 °C

8.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With hydrogenchloride; hydrogen; diisobutylaluminium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 1333115-59-5
(S)-2-(N-(5-((tert-butoxycarbonyl)amino)-1-phenylpentan-2-yl)-2-(trifluoromethoxy)phenylsulfonamido)acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogenchloride / 4 h / Reflux

2.1: sodium hydrogencarbonate / dichloromethane; water / 3 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

3.2: 20 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / methanol

6.1: triethylamine / dichloromethane / 12 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

8.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

9.1: triethylamine / dmap / dichloromethane / 12 h / 20 °C

10.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

With hydrogenchloride; hydrogen; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;