(S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

Base Information

Chemical Name:(S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine
CAS No.:1333115-63-1
Molecular Formula:C₂₂H₂₀F₆N₄O₃S
Molecular Weight:534.482
Hs Code.:

Synonyms:(S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

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Chemical Property of (S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

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Technology Process of (S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

There total 15 articles about (S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₂F₆N₄O₄S

: 1333115-63-1
(S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

Guidance literature:: C₂₂H₂₂F₆N₄O₄S; With toluene-4-sulfonic acid; In water; toluene; at 75 ℃; for 12h;

With potassium carbonate; In water; ethyl acetate; toluene;

Reference yield:

: 77119-85-8
N-(tert-butoxycarbonyl)-D-phenylalaninal

: 1333115-63-1
(S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

Guidance literature:: Multi-step reaction with 12 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol

3: triethylamine / dichloromethane / 12 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

5: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

6: triethylamine / dmap / dichloromethane / 12 h / 20 °C

7: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

8: trifluoroacetic acid / dichloromethane

9: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

10: Lawessons reagent / toluene / 0.5 h / 80 °C

11: mercury(II) diacetate / tetrahydrofuran / 2 h / 0 °C

12: toluene-4-sulfonic acid / water; toluene / 12 h / 75 °C

With Lawessons reagent; hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; mercury(II) diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 19901-50-9,51987-73-6,77119-84-7
methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate

: 1333115-63-1
(S)-8-benzyl-9-((2-(trifluoromethoxy)phenyl)sulfonyl)-3-(trifluoromethyl)-5,6,7,8,9,10-hexahydro-[1,2,4]triazolo[4,3-a][1,4]diazocine

Guidance literature:: Multi-step reaction with 13 steps

1.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / acetonitrile / 1.5 h / 20 °C / Inert atmosphere

3.1: hydrogenchloride / methanol

4.1: triethylamine / dichloromethane / 12 h / 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6.1: hydrogen; trifluoroacetic acid / platinum(IV) oxide; platinum on activated charcoal / methanol / 12 h / 2482.38 Torr

7.1: triethylamine / dmap / dichloromethane / 12 h / 20 °C

8.1: lithium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C

9.1: trifluoroacetic acid / dichloromethane

10.1: bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

11.1: Lawessons reagent / toluene / 0.5 h / 80 °C

12.1: mercury(II) diacetate / tetrahydrofuran / 2 h / 0 °C

13.1: toluene-4-sulfonic acid / water; toluene / 12 h / 75 °C

With Lawessons reagent; hydrogenchloride; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; diisobutylaluminium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; lithium hydroxide; dmap; platinum(IV) oxide; platinum on activated charcoal; mercury(II) diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;