(S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one

Base Information

Chemical Name:(S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one
CAS No.:1438417-84-5
Molecular Formula:C₂₂H₂₁FN₂O
Molecular Weight:348.42
Hs Code.:

Synonyms:(S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one

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Chemical Property of (S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one

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Technology Process of (S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one

There total 2 articles about (S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: C₂₂H₂₂FNO₃

: 1438417-84-5
(S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one

Guidance literature:: With ammonium acetate; In ethanol; at 32 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.04.003

Reference yield:

: 24582-72-7
3-(4-fluorophenyl)-1-(pyridin-2-yl)prop-2-en-1-one

: 126-81-8
dimedone

: 1438417-84-5
(S)-4-(4-fluorophenyl)-7,7-dimethyl-2-(pyridin-2-yl)-4,6,7,8-tetrahydroquinolin-5(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: C₂₈H₂₆F₆N₄O / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: ammonium acetate / ethanol / 4 h / 32 °C / Inert atmosphere

With C₂₈H₂₆F₆N₄O; ammonium acetate; In ethanol; dichloromethane; 1: |Michael Addition;
DOI:10.1016/j.tetlet.2013.04.003