24582-72-7Relevant academic research and scientific papers
Chiral bipyridine-annulated bicyclo[3.3.1]nonane N-oxide organocatalysts for stereoselective allylation and hydrosilylation reactions
?eimyt?, Simona,Ston?ius, Sigitas
, (2020/12/21)
The synthesis of chiral C2-symmetric bis(bipyridine N,N′-dioxide) and bis(bipyridine N-monooxide) derivatives featuring bipyridine-annulated bicyclo[3.3.1]nonane framework is reported. The new Lewis basic bipyridine N,N′-dioxides exhibited good
Fabrication of Copper-based Silica-coated Magnetic Nanocatalyst for Efficient One-pot Synthesis of Chalcones via A3 Coupling of Aldehydes-Alkynes-Amines
Yadav, Priya,Yadav, Manavi,Gaur, Rashmi,Gupta, Radhika,Arora, Gunjan,Rana, Pooja,Srivastava, Anju,Sharma, Rakesh K.
, p. 2488 - 2496 (2020/03/26)
In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica-coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility f
Design and development of a heterogeneous catalyst for the michael addition of malononitrile to 2-enoylpyridines: Influence of the primary amide decorated framework on catalytic activity and selectivity
Markad, Datta,Khullar, Sadhika,Mandal, Sanjay K.
supporting information, p. 12547 - 12554 (2019/10/11)
For the Michael addition of malononitrile to 2-enoylpyridines, we report the first heterogeneous catalyst, {[Zn2(2-bpbg)(fum)2]·4H2O·EtOH}n (1) (where 2-bpbg = N,N′-bis(2-pyridylmethyl)-1,4-diaminobutane-N,N′-di
Halo-substituted chalcones and azachalcones-inhibited, lipopolysaccharited-stimulated, pro-inflammatory responses through the TLR4-mediated pathway
Shih, Tzenge-Lien,Liu, Ming-Hwa,Li, Chia-Wai,Kuo, Chia-Feng
, (2018/03/21)
A series of B-ring, halo-substituted chalcones and azachalcones were synthesized to evaluate and compare their anti-inflammatory activity. Mouse BALB/c macrophage RAW 264.7 were pre-treated with 10 μg/mL of each compound for one hour before induction of i
Half Sandwich Rhodium(III) and Iridium(III) Complexes as Cytotoxic and Metallonuclease Agents
Vekariya, Pankajkumar A.,Karia, Parag S.,Bhatt, Bhupesh S.,Patel, Mohan N.
, p. 1 - 14 (2018/07/21)
Half sandwich complexes of the type [(η5-C5Me5)M(L1–3)Cl]Cl.2H2O were synthesized using [{(η5-C5Me5)M(μ-Cl)Cl}2], where M = Rh(III)/Ir(III) and L1–3 = pyrim
Synthesis and biological evaluation of fluoropyrazolesulfonylurea and thiourea derivatives as possible antidiabetic agents
Faidallah, Hassan M.,Al-Mohammadi, Manal M.,Alamry, Khalid A.,Khan, Khalid A.
, p. 157 - 163 (2016/12/03)
Fluorinated pyrazoles, benzenesulfonylurea and thiourea and their cyclic sulfonylthiourea derivatives were prepared as hypoglycemic agents. The chemistry involves the condensation of 4-hydrazino benzenesulfonamide hydrochloride with fluorochalcones to giv
Diastereo- and enantioselective direct vinylogous Michael addition of γ-substituted butenolides to 2-enoylpyridines catalyzed by chiral bifunctional amine-squaramides
Wang, Zhen-Hua,Wu, Zhi-Jun,Huang, Xue-Qun,Yue, Deng-Feng,You, Yong,Xu, Xiao-Ying,Zhang, Xiao-Mei,Yuan, Wei-Cheng
supporting information, p. 15835 - 15838 (2015/11/10)
The diastereo- and enantioselective direct vinylogous Michael addition reaction of γ-substituted butenolides to 2-enoylpyridines has been achieved. A range of γ,γ-disubstituted butenolide derivatives, bearing two consecutive tri- and tetrasubstituted stereogenic centers, were readily obtained in good yields with excellent stereoselectivities (up to >99:1 dr and >99% ee).
EGFR/HER-2 inhibitors: Synthesis, biological evaluation and 3D-QSAR analysis of dihydropyridine-containing thiazolinone derivatives
Ren, Yu-Jia,Wang, Zhong-Chang,Zhang, Xin,Qiu, Han-Yue,Wang, Peng-Fei,Gong, Hai-Bin,Jiang, Ai-Qin,Zhu, Hai-Liang
, p. 21445 - 21454 (2015/03/30)
A series of dihydropyridine containing thiazolinone derivatives (4a-4r) have been designed, synthesized and their biological activities evaluated as potential EGFR and HER-2 kinase inhibitors and in tumor cell antiproliferation. The synthesized compounds
Synthesis, pharmacological and biological screening of some novel pyrimidine derivatives
Ishwar Bhat,Kumar, Abhishek,Nisar, Muhammed,Kumar, Pankaj
, p. 3458 - 3467 (2014/06/24)
In the present study a new series of 4-substituted phenyl-6-(pyridin-2-yl) pyrimidin-2-ol (1-9) and 4-substituted phenyl-6-(pyridin-2-yl)pyrimidin-2-thiol (10-18) have been synthesized by cyclizing 3-substituted phenyl-1-(pyridin-2-yl) prop-2-en-1-one wit
