{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

Base Information

Chemical Name:{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid
CAS No.:911384-72-0
Molecular Formula:C₃₇H₄₅N₃O₁₄S₂
Molecular Weight:819.908
Hs Code.:

{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

Synonyms:{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

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Chemical Property of {2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

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Technology Process of {2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

There total 1 articles about {2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 313682-08-5
brecanavir

: 4480-83-5
1,4-dioxane-2,6-dione

: 911384-72-0
{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h;

Reference yield: 79.0%

: 27757-85-3
2-Aminomethylthiophene

: 911384-72-0
{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

: 911384-58-2
(1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl {2-oxo-2-[(thien-2-ylmethyl)amino]ethoxy}acetate

Guidance literature:: {2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 2h; Rocked at 800 Hz;

2-Aminomethylthiophene; In dichloromethane; N,N-dimethyl-formamide; for 24h; Rocked at 800 Hz;

Reference yield: 42.0%

: 911384-72-0
{2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid

: 1225387-53-0
3⁽⁵⁾-aminopyrazole

: 911384-56-0
(1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl [2-oxo-2-(2H-pyrazol-5-ylamino)ethoxy]acetate

Guidance literature:: {2-[((1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl)oxy]-2-oxoethoxy}acetic acid; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 0.5h; Rocked at 800 Hz;

3⁽⁵⁾-aminopyrazole; In dichloromethane; N,N-dimethyl-formamide; for 24h; Rocked at 800 Hz;