1225387-53-0

Basic information

• Product Name: 1H-PYRAZOL-5-AMINE
• Synonyms: AKOS PAO-0255;1H-PYRAZOL-5-AMINE;2H-Pyrazol-3-amine
• CAS NO: 1225387-53-0
• Molecular Formula: C₃H₅N₃
• Molecular Weight: 83.0919
• Mol File: 1225387-53-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1H-PYRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRAZOL-5-AMINE(1225387-53-0)
• EPA Substance Registry System: 1H-PYRAZOL-5-AMINE(1225387-53-0)

Safety Data

• Hazardous Substances Data: 1225387-53-0(Hazardous Substances Data)

Usage

General Description

1H-Pyrazol-5-amine, also known as pyrazolamine, is a chemical compound that belongs to the class of pyrazole derivatives. It is a heterocyclic organic compound containing a pyrazole ring with an amino group at the 5th position. This chemical is commonly used in pharmaceutical research and drug development due to its potential biological activities, including anti-inflammatory and analgesic properties. It is also used as a building block in the synthesis of various organic compounds and can serve as a precursor in the production of agrochemicals and other fine chemicals. Additionally, 1H-Pyrazol-5-amine has been studied for its potential applications in the field of materials science, such as in the development of organic light-emitting diodes (OLEDs) and other electronic devices.

Upstream product

• 6162-76-1 cyanoacetaldehyde 
• 2407-68-3 3-dimethylaminoacrylonitrile 
• 75-05-8 acetonitrile 
• 109-94-4 formic acid ethyl ester 
• 26621-44-3 5-nitro-1H-pyrazole 
• 106087-63-2 6-Nitro-4H-pyrazolo[1,5-a]pyrimidin-7-one 
• 3994-46-5 N-aminopyrazole 

Downstream Products

• 371249-01-3 3-(2H-pyrazol-3-ylamino)-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester 
• 16461-94-2 5-amino-4-bromo-1H-pyrazole 
• 755753-82-3 4,6-bis(4-fluorophenyl)-5-(4-pyridyl)-1H-pyrazolo[3,4-b]pyridine 
• 705263-10-1 6-bromo-pyrazolo[1,5-α]pyrimidine 
• 1062368-61-9 C₁₃H₁₁N₃O 
• 911384-56-0 (1R,2S)-2-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-1-{[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]methyl}-3-{4-[(2-methyl-1,3-thiazol-4-yl)methoxy]phenyl}propyl [2-oxo-2-(2H-pyrazol-5-ylamino)ethoxy]acetate 
• 57489-70-0 5,7-dihydroxypyrazolo[1,5-a]pyrimidine 
• 1235455-58-9 C₂₀H₂₃F₃N₆ 

Relevant articles and documents

The metabolism of a series of ester pro-drugs by NCTC 2544 cells, skin homogenate and LDE testskin

The metabolism of a series of substituted pyrazolopyridine ester pro-drugs was investigated using NCTC 2544 cells, human skin homogenate and LDE Testskin as model systems. The compounds were incubated in each system and the disappearance of drug and the production of the major hydrolysis product was observed with time and quantitated using HPLC. The toxicity of the ester pro-drugs and the metabolites was examined in NCTC 2544 cells using a cell viability assay procedure. Hydrolytic activity was slightly higher in the cell culture model than in skin homogenate solution but the rank order of activity for each pro-drug was similar. The metabolic activity of LDE Testskin was much reduced compared with the other systems, but again the overall pattern of metabolism was not dissimilar. These findings indicate that NCTC 2544 cells provide a reasonable model for human skin ester hydrolysis both in terms of rate and in terms of substrate specificity.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported.

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2

Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model.