2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

Base Information

Chemical Name:2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone
CAS No.:1469293-93-3
Molecular Formula:C₁₉H₁₈F₃N₅O₂
Molecular Weight:405.379
Hs Code.:

Synonyms:2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

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Chemical Property of 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

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Technology Process of 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

There total 4 articles about 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 110-91-8,99108-56-2
morpholine

: 1469293-82-0
ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

: 1469293-93-3
2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

Guidance literature:: With potassium carbonate; at 100 ℃; for 12h;
DOI:10.1016/j.bmcl.2013.08.089

Reference yield:

: 3335-44-2
2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 1469293-93-3
2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide; potassium carbonate / acetone / 6 h / Reflux

2: hydrazine hydrate / 6 h / 100 °C

3: sodium iodide; potassium carbonate / acetone / 24 h / Reflux

4: potassium carbonate / 12 h / 100 °C

With potassium carbonate; hydrazine hydrate; sodium iodide; In acetone;
DOI:10.1016/j.bmcl.2013.08.089

Reference yield:

: 2-O-acetamido-3-cyano-4-trifluoromethyl-6-phenylpyridine

: 1469293-93-3
2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-1-morpholinoethanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / 6 h / 100 °C

2: sodium iodide; potassium carbonate / acetone / 24 h / Reflux

3: potassium carbonate / 12 h / 100 °C

With potassium carbonate; hydrazine hydrate; sodium iodide; In acetone;
DOI:10.1016/j.bmcl.2013.08.089