ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

Base Information

Chemical Name:ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate
CAS No.:1469293-82-0
Molecular Formula:C₁₇H₁₅F₃N₄O₂
Molecular Weight:364.327
Hs Code.:

Synonyms:ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

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Chemical Property of ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

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Technology Process of ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

There total 4 articles about ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 105-36-2
ethyl bromoacetate

: 201224-86-4
6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

: 1469293-82-0
ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; for 24h; Reflux;
DOI:10.1016/j.bmcl.2013.08.089

Reference yield:

: 3335-44-2
2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

: 1469293-82-0
ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium iodide; potassium carbonate / acetone / 6 h / Reflux

2: hydrazine hydrate / 6 h / 100 °C

3: sodium iodide; potassium carbonate / acetone / 24 h / Reflux

With potassium carbonate; hydrazine hydrate; sodium iodide; In acetone;
DOI:10.1016/j.bmcl.2013.08.089

Reference yield:

: 2-O-acetamido-3-cyano-4-trifluoromethyl-6-phenylpyridine

: 1469293-82-0
ethyl 2-(3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / 6 h / 100 °C

2: sodium iodide; potassium carbonate / acetone / 24 h / Reflux

With potassium carbonate; hydrazine hydrate; sodium iodide; In acetone;
DOI:10.1016/j.bmcl.2013.08.089