cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

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Chemical Name:cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine
CAS No.:337902-47-3
Molecular Formula:C₂₅H₂₇FN₈
Molecular Weight:458.541
Hs Code.:

cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-<i>b</i>]pyridin-1-yl]-pyrimidin-2-yl}-amine

Synonyms:cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

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Chemical Property of cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

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Technology Process of cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

There total 6 articles about cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 827029-55-0
4-[1-(2-cyclopentylamino-pyrimidin-4-yl)-2-(4-fluoro-phenyl)-1H-imidazo[4,5-b]pyridin-5-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 337902-47-3
cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

Guidance literature:: With hydrogenchloride; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2004.03.106

Reference yield:

: 337902-85-9
5-Nitro-6-amino-2-(4-ethoxycarbonyl-1-piperazinyl)pyridine

: 337902-47-3
cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / H₂ / Pd/C / ethanol

2: 55 percent / polyphosphoric acid / 130 - 150 °C

3: 70 percent / Na₂CO₃ / ethyl acetate / 2 h / 20 °C

4: 55 percent / dimethylformamide / 2 h / 155 °C

5: 65 percent / mCPBA; AcOH / CH₂Cl₂ / 0.5 h / 0 °C

6: 1 h / 120 °C

7: 90 percent / aq. HCl / ethanol / 1 h / 20 °C

With hydrogenchloride; PPA; hydrogen; sodium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.106

Reference yield:

: 337902-86-0
5,6Diamino-2-(4-ethoxycarbonyl-1-piperazinyl)pyridine

: 337902-47-3
cyclopentyl-{4-[2-(4-fluoro-phenyl)-5-piperazin-1-yl-imidazo[4,5-b]pyridin-1-yl]-pyrimidin-2-yl}-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / polyphosphoric acid / 130 - 150 °C

2: 70 percent / Na₂CO₃ / ethyl acetate / 2 h / 20 °C

3: 55 percent / dimethylformamide / 2 h / 155 °C

4: 65 percent / mCPBA; AcOH / CH₂Cl₂ / 0.5 h / 0 °C

5: 1 h / 120 °C

6: 90 percent / aq. HCl / ethanol / 1 h / 20 °C

With hydrogenchloride; PPA; sodium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.03.106