2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

Base Information

Chemical Name:2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione
CAS No.:372102-46-0
Molecular Formula:C₃₃H₂₈ClNO₆S
Molecular Weight:602.107
Hs Code.:

Synonyms:2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

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Chemical Property of 2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

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Technology Process of 2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

There total 7 articles about 2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 372102-45-9
8-amino-3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4H-chromen-4-one

: 1633-82-5
3-chloro-n-propanesulfonyl chloride

: 372102-46-0
2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

Guidance literature:: 8-amino-3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4H-chromen-4-one; 3-chloro-n-propanesulfonyl chloride; With dmap; triethylamine; In dichloromethane;

With sodium hydroxide; In N,N-dimethyl-formamide; Further stages.;
DOI:10.1016/j.bmcl.2006.12.011

Reference yield:

: 941269-63-2
C₃₂H₂₆ClNO₅

: 372102-46-0
2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: (Boc)2O; DMAP / CH₂Cl₂

1.2: NaOH / methanol

1.3: AcCl / methanol

2.1: Et₃N; DMAP / CH₂Cl₂

2.2: 82 percent / aq. NaOH / dimethylformamide

With dmap; di-tert-butyl dicarbonate; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2006.12.011

Reference yield:

: C₂₅H₂₂ClNO₄

: 372102-46-0
2-{3-(benzyloxy)-2-[4-(benzyloxy)-3-chlorophenyl]-6-methyl-4-oxo-4H-chromen-8-yl}-1λ6-isothiazolidin-1,1-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂O₂; aq. NaOH / methanol

2.1: K₂CO₃ / acetone

3.1: (Boc)2O; DMAP / CH₂Cl₂

3.2: NaOH / methanol

3.3: AcCl / methanol

4.1: Et₃N; DMAP / CH₂Cl₂

4.2: 82 percent / aq. NaOH / dimethylformamide

With dmap; sodium hydroxide; di-tert-butyl dicarbonate; dihydrogen peroxide; potassium carbonate; triethylamine; In methanol; dichloromethane; acetone;
DOI:10.1016/j.bmcl.2006.12.011