1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Base Information

Chemical Name:1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid
CAS No.:1026600-74-7
Molecular Formula:C₂₆H₂₄F₃N₃O₅
Molecular Weight:515.489
Hs Code.:

Synonyms:1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Suppliers and Price of 1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

There total 35 articles about 1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6175-45-7
2,2-diethoxyacetophenone

: 1026600-74-7
1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) acetic acid, 3 Angstroem molecular sieves, 2.) NaBH₃CN / 1.) ethanol, 1 h, 2.) ethanol, RT, 2 d

2: triethylamine / CH₂Cl₂

3: conc. sulfuric acid / diethyl ether / 3 h

4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

6: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

7: nitromethane, aluminum chloride / benzene / 1 h

8: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; nitromethane; 3 A molecular sieve; sulfuric acid; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014

Reference yield:

: 157422-73-6
N-allyl-2,2-diethoxy-1-phenylethylamine

: 1026600-74-7
1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / CH₂Cl₂

2: conc. sulfuric acid / diethyl ether / 3 h

3: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

4: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

5: 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

6: nitromethane, aluminum chloride / benzene / 1 h

7: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

With sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; aluminium trichloride; sodium dihydrogen phosphate; nitromethane; sulfuric acid; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014

Reference yield:

: 157422-71-4
1-benzyl-7-cyanoindole-2-carboxylic acid

: 1026600-74-7
1-Oxo-3-phenyl-2-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-2,9-dihydro-1H-β-carboline-8-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: oxalyl chloride, N,N-dimethylformamide / CH₂Cl₂ / 1 h

2: triethylamine / CH₂Cl₂

3: 90 percent / conc. sulfuric acid / diethyl ether / 3 h

4: 1.) N-methylmorpholine N-oxide, osmium tetraoxide, 2.) sodium periodate / 1.) THF, H₂O, overnight, 2.) ethanol, H₂O, 2 h

5: sodium chlorite, sodium dihydrogen phosphate monohydrate / tetrahydrofuran; 2-methyl-propan-2-ol; various solvent(s); H₂O / 0.5 h

6: 73 percent / 1-hydroxybenzotriazole, triethylamine, 1-<3-(dimethylamino)propyl>-3-ethylcarbodimide / dimethylformamide

7: 83 percent / nitromethane, aluminum chloride / benzene / 1 h

8: 32 percent / sodium hypophosphite monohydrate, pyridine, acetic acid / Raney nickel / H₂O / 2 h / 60 °C

9: sodium chlorite, sodium dihydrogen phosphate / 2-methyl-propan-2-ol; tetrahydrofuran; various solvent(s); H₂O / 0.5 h

With pyridine; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; osmium(VIII) oxide; sodium hypophosphite; aluminium trichloride; sodium dihydrogen phosphate; oxalyl dichloride; nitromethane; sulfuric acid; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 4-methylmorpholine N-oxide; triethylamine; N,N-dimethyl-formamide; nickel; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1021/jm00001a014