1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

Base Information

Chemical Name:1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole
CAS No.:1452819-77-0
Molecular Formula:C₁₅H₁₉N₅
Molecular Weight:269.349
Hs Code.:

Synonyms:1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

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Chemical Property of 1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

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Technology Process of 1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

There total 10 articles about 1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1452819-74-7
1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

: 107-19-7
propargyl alcohol

: 1452819-77-0
1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 8.5h; Inert atmosphere;
DOI:10.1002/ejoc.201201467

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1452819-77-0
1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 10 steps

1.1: ammonium bicarbonate / water / 18 h / 25 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 25 °C / Inert atmosphere

4.1: hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 14.5 h / 0 - 25 °C / Inert atmosphere

6.1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C / Inert atmosphere

7.1: thionyl chloride / 3 h / 25 °C / Inert atmosphere

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C / Inert atmosphere

8.2: 72 h / 25 °C / Inert atmosphere

9.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 h / 25 °C / 760.05 Torr

10.1: caesium carbonate / N,N-dimethyl-formamide / 8.5 h / 25 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; ammonium bicarbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201201467

Reference yield:

: 14085-43-9
2-cyclohexyl-1H-imidazole

: 1452819-77-0
1-{[2-cyclohexyl-1-(prop-2-yn-1-yl)-1H-imidazol-4-yl]methyl}-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 25 °C / Inert atmosphere

3.1: hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 14.5 h / 0 - 25 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C / Inert atmosphere

6.1: thionyl chloride / 3 h / 25 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C / Inert atmosphere

7.2: 72 h / 25 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 h / 25 °C / 760.05 Torr

9.1: caesium carbonate / N,N-dimethyl-formamide / 8.5 h / 25 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201201467