1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

Base Information

Chemical Name:1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole
CAS No.:1452819-74-7
Molecular Formula:C₁₂H₁₇N₅
Molecular Weight:231.3
Hs Code.:

Synonyms:1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

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Chemical Property of 1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

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Technology Process of 1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

There total 9 articles about 1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1452819-73-6
1-[(1-benzyl-2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

: 1452819-74-7
1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 25 ℃; for 20h; under 760.051 Torr;
DOI:10.1002/ejoc.201201467

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1452819-74-7
1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium bicarbonate / water / 18 h / 25 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 25 °C / Inert atmosphere

4.1: hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

5.1: caesium carbonate / N,N-dimethyl-formamide / 14.5 h / 0 - 25 °C / Inert atmosphere

6.1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C / Inert atmosphere

7.1: thionyl chloride / 3 h / 25 °C / Inert atmosphere

8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C / Inert atmosphere

8.2: 72 h / 25 °C / Inert atmosphere

9.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 h / 25 °C / 760.05 Torr

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; ammonium bicarbonate; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201201467

Reference yield:

: 14085-43-9
2-cyclohexyl-1H-imidazole

: 1452819-74-7
1-[(2-cyclohexyl-1H-imidazol-4-yl)methyl]-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 25 °C / Inert atmosphere

3.1: hydrogenchloride / water / 2 h / 25 °C / Inert atmosphere

4.1: caesium carbonate / N,N-dimethyl-formamide / 14.5 h / 0 - 25 °C / Inert atmosphere

5.1: sodium tetrahydroborate / methanol / 3 h / 0 - 25 °C / Inert atmosphere

6.1: thionyl chloride / 3 h / 25 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C / Inert atmosphere

7.2: 72 h / 25 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; methanol / 20 h / 25 °C / 760.05 Torr

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201201467