(S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

Base Information

Chemical Name:(S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone
CAS No.:1021167-05-4
Molecular Formula:C₁₉H₂₉NO₂S
Molecular Weight:335.511
Hs Code.:

Synonyms:(S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

Chemical Property:

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Technology Process of (S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

There total 3 articles about (S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 930-68-7
cyclohexenone

: 862776-58-7
(S)-N-benzylidene-2-methylpropane-2-sulfinamide

: 557-20-0
diethylzinc

: 1021167-05-4
(S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

Guidance literature:: cyclohexenone; (S)-N-benzylidene-2-methylpropane-2-sulfinamide; With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

diethylzinc; In dichloromethane; toluene; at -40 - -20 ℃; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo802812w

Reference yield:

: 930-68-7
cyclohexenone

: 557-20-0
diethylzinc

: 186249-74-1
(S,E)-N-benzylidene-tert-butylsulfinamide

: 1021167-05-4
(S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

Guidance literature:: cyclohexenone; (S,E)-N-benzylidene-tert-butylsulfinamide; With chiral phosphoramidite ligand; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 0.5h;

diethylzinc; In hexane; dichloromethane; at -40 - -20 ℃; Further stages.;
DOI:10.1016/j.tetlet.2008.02.076

Reference yield:

: 930-68-7
cyclohexenone

: 557-20-0
diethylzinc

: 186249-74-1
(S,E)-N-benzylidene-tert-butylsulfinamide

: 1021167-05-4
(S(S),2R,3R,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

: 1021167-06-5
(S(S),2S,3S,1'R)-N-(tert-butylsulfinyl)-2-(aminophenylmethyl)-3-ethylcyclohexanone

Guidance literature:: cyclohexenone; (S,E)-N-benzylidene-tert-butylsulfinamide; With chiral phosphoramidite ligand; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 0.5h;

diethylzinc; In hexane; dichloromethane; at -40 - -20 ℃; Further stages.;
DOI:10.1016/j.tetlet.2008.02.076