Technology Process of (2S,3S,4R,5S,6R)-2-(3-(4-chlorobenzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate
There total 11 articles about (2S,3S,4R,5S,6R)-2-(3-(4-chlorobenzyl)-4-methylphenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C27H29ClO9;
With
trimethylsilyl trifluoromethanesulfonate; thiourea;
In
1,4-dioxane;
at 80 ℃;
for 4h;
methyl iodide;
With
N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane;
at 20 ℃;
for 24h;
- Guidance literature:
-
(3S,4R,5S,6S)-6-(3-(4-chlorobenzyl)-4-methylphenyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate;
With
trimethylsilyl trifluoromethanesulfonate; thiourea;
In
1,4-dioxane;
at 80 ℃;
for 3h;
methyl iodide;
With
N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane;
at 20 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 2 h / 0 - 60 °C
2.1: tert-butylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
2.2: 1.5 h / -78 - 60 °C
3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate; methanol; water; sodium hydroxide / 0.25 h
4.1: water; acetic acid / 7 h / 100 °C
5.1: dmap; triethylamine / acetonitrile / 1 h / 20 °C
6.1: thiourea; trimethylsilyl trifluoromethanesulfonate / 1,4-dioxane / 3 h / 80 °C
6.2: 18 h / 20 °C
With
methanol; triethylsilane; dmap; sodium tetrahydroborate; trimethylsilyl trifluoromethanesulfonate; cerium(III) chloride heptahydrate; boron trifluoride diethyl etherate; tert-butylmagnesium chloride; water; acetic acid; triethylamine; thiourea; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; acetonitrile;
