N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide
CAS No.:1314593-38-8
Molecular Formula:C₁₉H₁₆F₃NO₃
Molecular Weight:363.336
Hs Code.:

Synonyms:N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

Suppliers and Price of N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

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Technology Process of N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

There total 4 articles about N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 67515-49-5
1-benzyloxyallene

: 100-47-0
benzonitrile

: 76-05-1
trifluoroacetic acid

: 1173883-66-3
2-phenyl-3-benzyloxy-2-phenyl-6-trifluoromethylpyridin-4-ol

: 1314593-38-8
N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

Guidance literature:: 1-benzyloxyallene; With n-butyllithium; In hexanes; diethyl ether; at -40 ℃; for 0.416667h; Inert atmosphere;

benzonitrile; In hexanes; diethyl ether; at -78 ℃; Inert atmosphere;

trifluoroacetic acid; In hexanes; diethyl ether; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.200900386

Reference yield:

: 67515-49-5
1-benzyloxyallene

: 1173883-66-3
2-phenyl-3-benzyloxy-2-phenyl-6-trifluoromethylpyridin-4-ol

: 1314593-38-8
N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / -40 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: diethyl ether; hexane / -78 - 20 °C / Inert atmosphere

With n-butyllithium; In diethyl ether; hexane;
DOI:10.1002/chem.201100382

Reference yield:

: 100-47-0
benzonitrile

: 1173883-66-3
2-phenyl-3-benzyloxy-2-phenyl-6-trifluoromethylpyridin-4-ol

: 1314593-38-8
N-[(1E)-2-(benzyloxy)-3-oxo-1-phenylbut-1-enyl]-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / -40 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: diethyl ether; hexane / -78 - 20 °C / Inert atmosphere

With n-butyllithium; In diethyl ether; hexane;
DOI:10.1002/chem.201100382